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{
    "metadata": {
        "accession": "IPR044860",
        "entry_id": null,
        "type": "homologous_superfamily",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "cathgene3d": {
                "G3DSA:2.30.160.11": "G3DSA:2.30.160.11"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR044860",
            "name": "Methuselah ectodomain, domain 1",
            "type": "Homologous_superfamily",
            "children": []
        },
        "name": {
            "name": "Methuselah ectodomain, domain 1",
            "short": "Methusela_ecto_dom_1"
        },
        "description": [
            {
                "text": "<p>Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site [[cite:PUB00012777], [cite:PUB00048826]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            },
            {
                "text": "<p>This entry represents a structural subdomain found at the N-termimus of the Methusela ectodomain.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00012777": {
                "PMID": 11274391,
                "ISBN": null,
                "volume": "98",
                "issue": "7",
                "year": 2001,
                "title": "Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan.",
                "URL": null,
                "raw_pages": "3744-9",
                "medline_journal": "Proc Natl Acad Sci U S A",
                "ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
                "authors": [
                    "West AP Jr",
                    "Llamas LL",
                    "Snow PM",
                    "Benzer S",
                    "Bjorkman PJ."
                ],
                "DOI_URL": "http://dx.doi.org/10.1073/pnas.051625298"
            },
            "PUB00048826": {
                "PMID": 17546039,
                "ISBN": null,
                "volume": "3",
                "issue": "7",
                "year": 2007,
                "title": "Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor.",
                "URL": null,
                "raw_pages": "415-9",
                "medline_journal": "Nat Chem Biol",
                "ISO_journal": "Nat. Chem. Biol.",
                "authors": [
                    "Ja WW",
                    "West AP Jr",
                    "Delker SL",
                    "Bjorkman PJ",
                    "Benzer S",
                    "Roberts RW."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/nchembio.2007.2"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR051384",
                "name": "Methuselah G-protein coupled receptor",
                "type": "family"
            },
            {
                "accession": "IPR036272",
                "name": "Methuselah, N-terminal domain superfamily",
                "type": "homologous_superfamily"
            },
            {
                "accession": "IPR010596",
                "name": "Methuselah, N-terminal domain",
                "type": "domain"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 616,
            "pathways": 0,
            "proteins": 594,
            "proteomes": 63,
            "sets": 0,
            "structural_models": {
                "alphafold": 532,
                "bfvd": 0
            },
            "structures": 2,
            "taxa": 249
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}