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{
    "metadata": {
        "accession": "IPR044786",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "cdd": {
                "cd04336": "YeaK"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR044786",
            "name": "Multifunctional Ser/Thr-tRNA deacylase ProXp-y",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Multifunctional Ser/Thr-tRNA deacylase ProXp-y",
            "short": "PROXY"
        },
        "description": [
            {
                "text": "<p>Multifunctional Ser/Thr-tRNA deacylase ProXp-y (formerly known as YeaK) is an aminoacyl-tRNA editing enzyme that deacylates Ser-tRNA and/or Thr-tRNA mischarged by lysyl-tRNA synthetase (LysRS), threonyl-tRNA synthetase (ThrRS), seryl_tRNA synthetase (SerRS), alanyl-tRNA synthetase (AlaRS), valyl-tRNA synthetase (ValRS) and isoleucyl-tRNA synthetase (IleRS) in vitro. However, it may be required in vivo to prevent mistranslation and to maintain growth when the error prone stress-inducible lysyl-tRNA synthetase (LysU) is expressed under environmental pressure [[cite:PUB00101865]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00101865": {
                "PMID": 25918376,
                "ISBN": null,
                "volume": "112",
                "issue": "19",
                "year": 2015,
                "title": "Homologous trans-editing factors with broad tRNA specificity prevent mistranslation caused by serine/threonine misactivation.",
                "URL": null,
                "raw_pages": "6027-32",
                "medline_journal": "Proc Natl Acad Sci U S A",
                "ISO_journal": "Proc Natl Acad Sci U S A",
                "authors": [
                    "Liu Z",
                    "Vargas-Rodriguez O",
                    "Goto Y",
                    "Novoa EM",
                    "Ribas de Pouplana L",
                    "Suga H",
                    "Musier-Forsyth K."
                ],
                "DOI_URL": null
            },
            "PUB00041604": {
                "PMID": 17027500,
                "ISBN": null,
                "volume": "14",
                "issue": "10",
                "year": 2006,
                "title": "Structures of two bacterial prolyl-tRNA synthetases with and without a cis-editing domain.",
                "URL": null,
                "raw_pages": "1511-25",
                "medline_journal": "Structure",
                "ISO_journal": "Structure",
                "authors": [
                    "Crepin T",
                    "Yaremchuk A",
                    "Tukalo M",
                    "Cusack S."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/j.str.2006.08.007"
            },
            "PUB00010589": {
                "PMID": 10813833,
                "ISBN": null,
                "volume": "40",
                "issue": "1",
                "year": 2000,
                "title": "Crystal structure of YbaK protein from Haemophilus influenzae (HI1434) at 1.8 A resolution: functional implications.",
                "URL": null,
                "raw_pages": "86-97",
                "medline_journal": "Proteins",
                "ISO_journal": "Proteins",
                "authors": [
                    "Zhang H",
                    "Huang K",
                    "Li Z",
                    "Banerjei L",
                    "Fisher KE",
                    "Grishin NV",
                    "Eisenstein E",
                    "Herzberg O."
                ],
                "DOI_URL": "http://dx.doi.org/10.1002/(SICI)1097-0134(20000701)40:1<86::AID-PROT100>3.0.CO;2-Y"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR036754",
                "name": "YbaK/aminoacyl-tRNA synthetase-associated domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 1444,
            "pathways": 0,
            "proteins": 1444,
            "proteomes": 481,
            "sets": 0,
            "structural_models": {
                "alphafold": 1254,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 1169
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}