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{
    "metadata": {
        "accession": "IPR044623",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0036503",
                "name": "ERAD pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR45084": "ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3A-RELATED"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR044623",
            "name": "ERAD-associated E3 ubiquitin-protein ligase component HRD3",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "ERAD-associated E3 ubiquitin-protein ligase component HRD3",
            "short": "HRD3"
        },
        "description": [
            {
                "text": "<p>This entry includes HRD3 and related proteins from plants. In Arabidopsis there are two homologues, HRD3A and HRD3B. HRD3 is part of the HRD1/HRD3 complex involved in the ERAD (endoplasmic reticulum and subsequently degraded by ER-associated degradation) pathway [[cite:PUB00096551]]. HRD3A is involved in salt acclimation memory [[cite:PUB00096550]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00096550": {
                "PMID": 30450762,
                "ISBN": null,
                "volume": "61",
                "issue": "10",
                "year": 2019,
                "title": "Basic-leucine zipper 17 and Hmg-CoA reductase degradation 3A are involved in salt acclimation memory in Arabidopsis.",
                "URL": null,
                "raw_pages": "1062-1084",
                "medline_journal": "J Integr Plant Biol",
                "ISO_journal": "J Integr Plant Biol",
                "authors": [
                    "Tian L",
                    "Zhang Y",
                    "Kang E",
                    "Ma H",
                    "Zhao H",
                    "Yuan M",
                    "Zhu L",
                    "Fu Y."
                ],
                "DOI_URL": null
            },
            "PUB00096551": {
                "PMID": 21187857,
                "ISBN": null,
                "volume": "21",
                "issue": "6",
                "year": 2011,
                "title": "The endoplasmic reticulum-associated degradation is necessary for plant salt tolerance.",
                "URL": null,
                "raw_pages": "957-69",
                "medline_journal": "Cell Res",
                "ISO_journal": "Cell Res.",
                "authors": [
                    "Liu L",
                    "Cui F",
                    "Li Q",
                    "Yin B",
                    "Zhang H",
                    "Lin B",
                    "Wu Y",
                    "Xia R",
                    "Tang S",
                    "Xie Q."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 1142,
            "pathways": 0,
            "proteins": 1142,
            "proteomes": 456,
            "sets": 0,
            "structural_models": {
                "alphafold": 995,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 1822
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}