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{
"metadata": {
"accession": "IPR043575",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0030971",
"name": "receptor tyrosine kinase binding",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"pirsf": {
"PIRSF500185": "Macrophage stimulating protein"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001314",
"name": "Peptidase S1A, chymotrypsin family",
"type": "Family",
"children": [
{
"accession": "IPR003966",
"name": "Prothrombin/thrombin",
"type": "Family",
"children": []
},
{
"accession": "IPR008292",
"name": "Haptoglobin",
"type": "Family",
"children": []
},
{
"accession": "IPR011163",
"name": "Peptidase S1A, enteropeptidase",
"type": "Family",
"children": []
},
{
"accession": "IPR011360",
"name": "Complement B/C2",
"type": "Family",
"children": [
{
"accession": "IPR028341",
"name": "Complement factor B",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR012224",
"name": "Peptidase S1A, coagulation factor VII/IX/X/C/Z",
"type": "Family",
"children": []
},
{
"accession": "IPR012267",
"name": "Peptidase S1A, acrosin",
"type": "Family",
"children": []
},
{
"accession": "IPR014394",
"name": "Coagulation factor XII/hepatocyte growth factor activator",
"type": "Family",
"children": []
},
{
"accession": "IPR017118",
"name": "Peptidase S1A, matriptase-2",
"type": "Family",
"children": []
},
{
"accession": "IPR017324",
"name": "Transmembrane protease serine 9",
"type": "Family",
"children": []
},
{
"accession": "IPR017326",
"name": "Peptidase S1A, polyserase-2",
"type": "Family",
"children": []
},
{
"accession": "IPR017327",
"name": "Peptidase S1A, TMPRSS13",
"type": "Family",
"children": []
},
{
"accession": "IPR017329",
"name": "Peptidase S1A, HAT/DESC1",
"type": "Family",
"children": []
},
{
"accession": "IPR023317",
"name": "Peptidase S1A, plasmin",
"type": "Family",
"children": []
},
{
"accession": "IPR024174",
"name": "Hepatocyte growth factor/Macrophage stimulatory protein",
"type": "Family",
"children": [
{
"accession": "IPR027284",
"name": "Hepatocyte growth factor",
"type": "Family",
"children": []
},
{
"accession": "IPR043575",
"name": "Macrophage stimulating protein",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR024175",
"name": "Peptidase S1A, complement C1r/C1S/mannan-binding",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "Macrophage stimulating protein",
"short": "MSP_HGFL"
},
"description": [
{
"text": "<p>Macrophage stimulating protein (MSP; also known as hepatocyte growth factor-like protein) and its close relative hepatocyte growth factor ([pirsf:PIRSF500183]) are non-peptidase homologues belonging to MEROPS peptidase family S1 (chymotrypsin family, clan PA(S)), subfamily S1A.</p>\n\n<p>MSP is a plasma protein that is secreted from the liver into the circulation as a single-chain, biologically inactive pro-protein. Proteolytic cleavage at a single site yields the active molecule composed of disulphide-linked alpha and beta chains. The MSP receptor is a transmembrane tyrosine kinase found in murine resident peritoneal macrophages but not exudate macrophages or blood monocytes. MSP induces phosphorylation of the receptor cytoplasmic domain, association of phosphatidylinositol (PI)-3 kinase with the receptor, and phosphorylation of receptor-bound PI-3 kinase. MSP may function in tissue injury or wound healing [[cite:PUB00027859]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00027859": {
"PMID": 9524771,
"ISBN": null,
"volume": "212",
"issue": null,
"year": 1997,
"title": "Biological aspects of macrophage-stimulating protein (MSP) and its receptor.",
"URL": null,
"raw_pages": "183-91; discussion 192-7",
"medline_journal": "Ciba Found Symp",
"ISO_journal": "Ciba Found. Symp.",
"authors": [
"Leonard EJ."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 132,
"pathways": 2,
"proteins": 132,
"proteomes": 93,
"sets": 0,
"structural_models": {
"alphafold": 117,
"bfvd": 0
},
"structures": 0,
"taxa": 337
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
