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{
    "metadata": {
        "accession": "IPR043100",
        "entry_id": null,
        "type": "homologous_superfamily",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "cathgene3d": {
                "G3DSA:3.40.190.190": "CypI, domain 2"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR043100",
            "name": "Extracytoplasmic thiamine-binding lipoprotein, domain II",
            "type": "Homologous_superfamily",
            "children": []
        },
        "name": {
            "name": "Extracytoplasmic thiamine-binding lipoprotein, domain II",
            "short": "CypI_dom_II"
        },
        "description": [
            {
                "text": "<p>Thiamine-binding lipoprotein (Cypl) and related proteins are specific to Mycoplasma species. Cypl, also known as p37, whose gene is part of an operon encoding two additional proteins, which are highly similar to components of the periplasmic binding-protein-dependent transport systems of Gram-negative bacteria. It has been suggested that p37 is part of a homologous, high-affinity transport system in Mycoplasma hyorhinis, a Gram-positive bacterium [[cite:PUB00012775]]. Its structure indicates that it is a thiamine pyrophosphate-binding protein [[cite:PUB00051724]]. The monomer is a mixed α/β fold split into two globular domains (domains I and II) connected by two linker regions and the C-terminal helix.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            },
            {
                "text": "<p>This entry represents domain II, which consists of five β strands and five α helices.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00051724": {
                "PMID": 19233924,
                "ISBN": null,
                "volume": "191",
                "issue": "8",
                "year": 2009,
                "title": "Structural insights into the extracytoplasmic thiamine-binding lipoprotein p37 of Mycoplasma hyorhinis.",
                "URL": null,
                "raw_pages": "2585-92",
                "medline_journal": "J Bacteriol",
                "ISO_journal": "J. Bacteriol.",
                "authors": [
                    "Sippel KH",
                    "Robbins AH",
                    "Reutzel R",
                    "Boehlein SK",
                    "Namiki K",
                    "Goodison S",
                    "Agbandje-McKenna M",
                    "Rosser CJ",
                    "McKenna R."
                ],
                "DOI_URL": "http://dx.doi.org/10.1128/JB.01680-08"
            },
            "PUB00012775": {
                "PMID": 3208756,
                "ISBN": null,
                "volume": "7",
                "issue": "12",
                "year": 1988,
                "title": "A mycoplasma high-affinity transport system and the in vitro invasiveness of mouse sarcoma cells.",
                "URL": null,
                "raw_pages": "3963-70",
                "medline_journal": "EMBO J",
                "ISO_journal": "EMBO J.",
                "authors": [
                    "Dudler R",
                    "Schmidhauser C",
                    "Parish RW",
                    "Wettenhall RE",
                    "Schmidt T."
                ],
                "DOI_URL": "http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=3208756&action=stream&blobtype=pdf"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR043099",
                "name": "Thiamine-binding lipoprotein, domain I",
                "type": "homologous_superfamily"
            },
            {
                "accession": "IPR010592",
                "name": "Extracytoplasmic thiamine-binding lipoprotein",
                "type": "family"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 177,
            "pathways": 0,
            "proteins": 177,
            "proteomes": 93,
            "sets": 0,
            "structural_models": {
                "alphafold": 154,
                "bfvd": 1
            },
            "structures": 4,
            "taxa": 178
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "3myu",
            "name": "Mycoplasma genitalium MG289"
        }
    }
}