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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR042377",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0012501",
"name": "programmed cell death",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"panther": {
"PTHR15207": "NONSYNDROMIC HEARING IMPAIRMENT PROTEIN"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR042377",
"name": "Gasdermin-E",
"type": "Family",
"children": []
},
"name": {
"name": "Gasdermin-E",
"short": "GSDME"
},
"description": [
{
"text": "<p>Gasdermin-E, also known as DFNA5, is involved in the p53-regulated cellular response to response to DNA damage probably by cooperating with p53 [[cite:PUB00092919]]. It can be cleaved by CASP3 into two parts: GSDME-N and GSDME-C. The GSDME-N fragment can perforate membranes and thereby induce pyroptosis [[cite:PUB00088060]]. Purified GSDME-N has been shown to efficiently lyse phosphoinositide/cardiolipin-containing liposomes and form pores on membranes made of artificial or natural phospholipid mixtures [[cite:PUB00088058]].</p>\n\n<p>This entry also includes Pejvakin, a gasdermin family member. It is a peroxisome-associated protein required to protect auditory hair cells against noise-induced damage [[cite:PUB00101502]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00101502": {
"PMID": 30936319,
"ISBN": null,
"volume": "116",
"issue": "16",
"year": 2019,
"title": "Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage.",
"URL": null,
"raw_pages": "8010-8017",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Defourny J",
"Aghaie A",
"Perfettini I",
"Avan P",
"Delmaghani S",
"Petit C."
],
"DOI_URL": null
},
"PUB00088060": {
"PMID": 28459430,
"ISBN": null,
"volume": "547",
"issue": "7661",
"year": 2017,
"title": "Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.",
"URL": null,
"raw_pages": "99-103",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Wang Y",
"Gao W",
"Shi X",
"Ding J",
"Liu W",
"He H",
"Wang K",
"Shao F."
],
"DOI_URL": "https://doi.org/10.1038/nature22393"
},
"PUB00092919": {
"PMID": 16897187,
"ISBN": null,
"volume": "51",
"issue": "8",
"year": 2006,
"title": "The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage.",
"URL": null,
"raw_pages": "652-64",
"medline_journal": "J Hum Genet",
"ISO_journal": "J. Hum. Genet.",
"authors": [
"Masuda Y",
"Futamura M",
"Kamino H",
"Nakamura Y",
"Kitamura N",
"Ohnishi S",
"Miyamoto Y",
"Ichikawa H",
"Ohta T",
"Ohki M",
"Kiyono T",
"Egami H",
"Baba H",
"Arakawa H."
],
"DOI_URL": null
},
"PUB00088058": {
"PMID": 27281216,
"ISBN": null,
"volume": "535",
"issue": "7610",
"year": 2016,
"title": "Pore-forming activity and structural autoinhibition of the gasdermin family.",
"URL": null,
"raw_pages": "111-6",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Ding J",
"Wang K",
"Liu W",
"She Y",
"Sun Q",
"Shi J",
"Sun H",
"Wang DC",
"Shao F."
],
"DOI_URL": "https://doi.org/10.1038/nature18590"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 2258,
"pathways": 9,
"proteins": 2258,
"proteomes": 774,
"sets": 0,
"structural_models": {
"alphafold": 2075,
"bfvd": 0
},
"structures": 3,
"taxa": 2464
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "8jyv",
"name": "Crystal structure of the gasdermin from Trichoplax adhaerens"
}
}
}
