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{
"metadata": {
"accession": "IPR042209",
"entry_id": null,
"type": "homologous_superfamily",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cathgene3d": {
"G3DSA:1.20.1280.150": "Hepatitis C virus non-structural protein NS2, N-terminal domain"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR042209",
"name": "Hepatitis C virus non-structural protein NS2, N-terminal domain",
"type": "Homologous_superfamily",
"children": []
},
"name": {
"name": "Hepatitis C virus non-structural protein NS2, N-terminal domain",
"short": "HCV_NS2_N"
},
"description": [
{
"text": "<p>This superfamily represents the N-terminal domain of hepatitis C virus non-structural protein NS2.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>The viral genome is translated into a single polyprotein of about 3000 amino acids. Generation of the mature non-structural proteins relies on the activity of viral proteases. Non-structural protein 2 (NS2) is an zinc-dependent autocatalytic endopeptidase which cleaves at the NS2/NS3 junction [[cite:PUB00000745], [cite:PUB00003531]]. The action of NS3 proteinase, which resides in the N-terminal one-third of the NS3 protein, then yields all remaining non-structural proteins.</p>\r\n\r\n<p>NS2 belongs to MEROPS peptidase family C18 (hepatitis C virus endopeptidase 2, clan CM). The fold consists of two subdomains connected by an extended linker: an N-terminal helical domain and a C-terminal β sheet. Peptidases are active as a homodimer and the two active sites are formed at the dimer interface by His and Glu from one monomer and Cys from the other. The dimer resembles a 'butterfly' with two-fold symmetry along the vertical axis. The N-terminal subdomain of one molecule interacts with the C-terminal subdomain of the other molecule and vice versa [[cite:PUB00041366]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00003531": {
"PMID": 9261354,
"ISBN": null,
"volume": "71",
"issue": "9",
"year": 1997,
"title": "In vitro study of the NS2-3 protease of hepatitis C virus.",
"URL": null,
"raw_pages": "6373-80",
"medline_journal": "J Virol",
"ISO_journal": "J. Virol.",
"authors": [
"Pieroni L",
"Santolini E",
"Fipaldini C",
"Pacini L",
"Migliaccio G",
"La Monica N."
],
"DOI_URL": "http://jvi.asm.org/cgi/content/abstract/71/9/6373"
},
"PUB00000745": {
"PMID": 9224925,
"ISBN": null,
"volume": "378",
"issue": "6",
"year": 1997,
"title": "The nonstructural proteins of the hepatitis C virus: structure and functions.",
"URL": null,
"raw_pages": "469-76",
"medline_journal": "Biol Chem",
"ISO_journal": "Biol. Chem.",
"authors": [
"Neddermann P",
"Tomei L",
"Steinkuhler C",
"Gallinari P",
"Tramontano A",
"De Francesco R."
],
"DOI_URL": null
},
"PUB00041366": {
"PMID": 16862121,
"ISBN": null,
"volume": "442",
"issue": "7104",
"year": 2006,
"title": "Structure of the catalytic domain of the hepatitis C virus NS2-3 protease.",
"URL": null,
"raw_pages": "831-5",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Lorenz IC",
"Marcotrigiano J",
"Dentzer TG",
"Rice CM."
],
"DOI_URL": "http://dx.doi.org/10.1038/nature04975"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR002518",
"name": "Hepatitis C virus, Non-structural protein NS2",
"type": "domain"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 14045,
"pathways": 7,
"proteins": 14044,
"proteomes": 4,
"sets": 0,
"structural_models": {
"alphafold": 0,
"bfvd": 23
},
"structures": 1,
"taxa": 172
},
"entry_annotations": {},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "2.7.7.48",
"url": "https://enzyme.expasy.org/EC/2.7.7.48"
},
{
"accession": "3.4.21.98",
"url": "https://enzyme.expasy.org/EC/3.4.21.98"
},
{
"accession": "3.4.22.-",
"url": "https://enzyme.expasy.org/EC/3.4.22.-"
},
{
"accession": "3.6.1.15",
"url": "https://enzyme.expasy.org/EC/3.6.1.15"
},
{
"accession": "3.6.4.13",
"url": "https://enzyme.expasy.org/EC/3.6.4.13"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
