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{
"metadata": {
"accession": "IPR042019",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd15683": "PHD finger found in inhibitor of growth protein 2 (ING2)"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001965",
"name": "Zinc finger, PHD-type",
"type": "Domain",
"children": [
{
"accession": "IPR019787",
"name": "Zinc finger, PHD-finger",
"type": "Domain",
"children": [
{
"accession": "IPR028940",
"name": "Bromodomain adjacent to zinc finger domain protein 2A, PHD zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR031202",
"name": "PHD finger protein 1, PHD finger 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR037373",
"name": "Transcription intermediary factor 1-beta, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037877",
"name": "HMT2C, PHD3",
"type": "Domain",
"children": []
},
{
"accession": "IPR039054",
"name": "Int12, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR039546",
"name": "Jade-1, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR039548",
"name": "JADE2, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR039550",
"name": "JADE3, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041947",
"name": "PHF13, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR042008",
"name": "BRPF1, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042009",
"name": "BRPF2, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042010",
"name": "ATX1/2, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042011",
"name": "ATX3/4/5, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042014",
"name": "MTF2, PHD domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR042019",
"name": "ING2, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042020",
"name": "ING3, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042023",
"name": "KMT2A, PHD domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR042025",
"name": "KMT2A, PHD domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR044075",
"name": "PRKCBP1, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR044104",
"name": "Alfin1-like, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR044133",
"name": "KMT2A, PHD domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR045876",
"name": "Pathogenesis-related homeodomain protein, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR046999",
"name": "KMT2D, PHD5 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047000",
"name": "KMT2D, PHD3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047003",
"name": "KMT2C, PHD4 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047004",
"name": "KMT2C, PHD2 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047005",
"name": "KMT2C, PHD6 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047256",
"name": "Tyrosine-protein kinase BAZ1B, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047426",
"name": "Histone-lysine N-methyltransferase NSD1 / NSD2, first PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047430",
"name": "Nuclear receptor-binding SET domain-containing protein 1, fourth PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047467",
"name": "E3 ubiquitin-protein ligase UHRF2, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047970",
"name": "Lysine-specific demethylase 5A, second PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047972",
"name": "Lysine-specific demethylase 5A, third PHD-finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047973",
"name": "Lysine-specific demethylase 5A, first PHD-finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047978",
"name": "Lysine-specific demethylase 5B, first PHD-finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047979",
"name": "Lysine-specific demethylase 5B, third PHD-finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR049781",
"name": "AF-10/AF-17, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR058054",
"name": "PHD finger protein MALE STERILITY 1-like, Zinc finger",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR034732",
"name": "Extended PHD (ePHD) domain",
"type": "Domain",
"children": [
{
"accession": "IPR039549",
"name": "JADE2, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041955",
"name": "ATX3/4/5, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041956",
"name": "ATX1/2, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041958",
"name": "KMT2A, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041959",
"name": "KMT2B, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041961",
"name": "KMT2D, ePHD1 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041964",
"name": "KMT2D, ePHD2 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041967",
"name": "KMT2C, ePHD1",
"type": "Domain",
"children": []
},
{
"accession": "IPR041968",
"name": "KMT2C, ePHD2",
"type": "Domain",
"children": []
},
{
"accession": "IPR041972",
"name": "Transcription factor 20, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042004",
"name": "BRPF2, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042005",
"name": "BRPF3, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042013",
"name": "PHF7/G2E3, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042061",
"name": "Peregrin, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047482",
"name": "Lysine-specific demethylase 4A, extended PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR049775",
"name": "AF-10, extended PHD finger",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR039095",
"name": "Transcription factor 19, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR042015",
"name": "MTF2, PHD domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR042017",
"name": "PHF19, PHD domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR043319",
"name": "ASH1-like, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047010",
"name": "PHD finger protein 1, PHD finger 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR047432",
"name": "Nuclear receptor-binding SET domain-containing protein 1, fifth PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047442",
"name": "Nuclear SET domain-containing protein 2, fifth PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047458",
"name": "Histone-lysine N-methyltransferase NSD3, fourth PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047527",
"name": "Histone-lysine N-methyltransferase NSD3, fifth PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR055197",
"name": "Histone-lysine N-methyltransferase NSD-like, variant PHD zinc finger",
"type": "Domain",
"children": [
{
"accession": "IPR047429",
"name": "Nuclear receptor-binding SET domain-containing protein 1, third PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047441",
"name": "Nuclear SET domain-containing protein 2, third PHD finger",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR055198",
"name": "Histone-lysine N-methyltransferase NSD-like, PHD zinc finger",
"type": "Domain",
"children": [
{
"accession": "IPR047428",
"name": "Nuclear receptor-binding SET domain-containing protein 1, second PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047439",
"name": "Nuclear SET domain-containing protein 2, second PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047456",
"name": "Histone-lysine N-methyltransferase NSD3, second PHD finger",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR059102",
"name": "PHF7/G2E3-like, PHD zinc finger domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "ING2, PHD domain",
"short": "ING2_PHD"
},
"description": [
{
"text": "<p>This entry represents the PHD domain of ING2.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Members of the ING (inhibitor of growth protein) family of tumour suppressors regulate cell cycle progression, senescence, apoptosis, and DNA repair as important cofactors of p53. Inhibitor of growth protein 2 (ING2) seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53 [[cite:PUB00069013]]. It is also a component of a chromatin-modifying complex containing the transcriptional co-repressor SIN3A and HDAC1 (histone deacetylase 1), which is involved in deacetylation of nucleosomal histones [[cite:PUB00069007], [cite:PUB00054915]]. The stability of ING2 is regulated by nuclear phosphatidylinositol-5-phosphate at discrete chromatin targets in response to DNA damage [[cite:PUB00069014], [cite:PUB00069015]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00069015": {
"PMID": 23823870,
"ISBN": null,
"volume": "3",
"issue": null,
"year": 2013,
"title": "Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage.",
"URL": null,
"raw_pages": "2137",
"medline_journal": "Sci Rep",
"ISO_journal": "Sci Rep",
"authors": [
"Bua DJ",
"Martin GM",
"Binda O",
"Gozani O."
],
"DOI_URL": "http://dx.doi.org/10.1038/srep02137"
},
"PUB00069013": {
"PMID": 11481424,
"ISBN": null,
"volume": "98",
"issue": "17",
"year": 2001,
"title": "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.",
"URL": null,
"raw_pages": "9671-6",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Nagashima M",
"Shiseki M",
"Miura K",
"Hagiwara K",
"Linke SP",
"Pedeux R",
"Wang XW",
"Yokota J",
"Riabowol K",
"Harris CC."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.161151798"
},
"PUB00069014": {
"PMID": 12859901,
"ISBN": null,
"volume": "114",
"issue": "1",
"year": 2003,
"title": "The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.",
"URL": null,
"raw_pages": "99-111",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Gozani O",
"Karuman P",
"Jones DR",
"Ivanov D",
"Cha J",
"Lugovskoy AA",
"Baird CL",
"Zhu H",
"Field SJ",
"Lessnick SL",
"Villasenor J",
"Mehrotra B",
"Chen J",
"Rao VR",
"Brugge JS",
"Ferguson CG",
"Payrastre B",
"Myszka DG",
"Cantley LC",
"Wagner G",
"Divecha N",
"Prestwich GD",
"Yuan J."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0092-8674(03)00480-X"
},
"PUB00054915": {
"PMID": 20676127,
"ISBN": null,
"volume": "29",
"issue": "44",
"year": 2010,
"title": "Sumoylation of ING2 regulates the transcription mediated by Sin3A.",
"URL": null,
"raw_pages": "5946-56",
"medline_journal": "Oncogene",
"ISO_journal": "Oncogene",
"authors": [
"Ythier D",
"Larrieu D",
"Binet R",
"Binda O",
"Brambilla C",
"Gazzeri S",
"Pedeux R."
],
"DOI_URL": "http://dx.doi.org/10.1038/onc.2010.325"
},
"PUB00069007": {
"PMID": 16387653,
"ISBN": null,
"volume": "21",
"issue": "1",
"year": 2006,
"title": "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.",
"URL": null,
"raw_pages": "51-64",
"medline_journal": "Mol Cell",
"ISO_journal": "Mol. Cell",
"authors": [
"Doyon Y",
"Cayrou C",
"Ullah M",
"Landry AJ",
"Cote V",
"Selleck W",
"Lane WS",
"Tan S",
"Yang XJ",
"Cote J."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.molcel.2005.12.007"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR011011",
"name": "Zinc finger, FYVE/PHD-type",
"type": "homologous_superfamily"
},
{
"accession": "IPR013083",
"name": "Zinc finger, RING/FYVE/PHD-type",
"type": "homologous_superfamily"
}
],
"counters": {
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"domain_architectures": 0,
"interactions": 0,
"matches": 681,
"pathways": 4,
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"proteomes": 590,
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"structural_models": {
"alphafold": 646,
"bfvd": 0
},
"structures": 1,
"taxa": 1804
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
