General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "IPR040134",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR10855": "26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR040134",
            "name": "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4",
            "short": "PSMD12/CSN4"
        },
        "description": [
            {
                "text": "<p>The 26S proteasome consists of a 20S proteolytic core particle (CP) and a 19S regulatory particle (RP). The RP can be further divided into two subcomplexes, the base that directly associates with the CP and a peripheral lid. The RP lid is structurally similar to the COP9 signalosome (CSN). The core CSN subunits (CSN4/5/7/6) show a remarkable one-to-one sequence correspondence with those of the RP lid (RPN5/11/9/8), suggesting a common ancestry and architecture [[cite:PUB00033528]].</p>\r\n\r\n<p>This family includes the 26S Proteasome non-ATPase regulatory subunit 12 (PSMD12 or RPN5), a component of the 26S proteasome lid [[cite:PUB00085267]], and the COP9 signalosome subunit 4 [[cite:PUB00088094]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00088094": {
                "PMID": 18926707,
                "ISBN": null,
                "volume": "33",
                "issue": "12",
                "year": 2008,
                "title": "The COP9 signalosome: more than a protease.",
                "URL": null,
                "raw_pages": "592-600",
                "medline_journal": "Trends Biochem Sci",
                "ISO_journal": "Trends Biochem. Sci.",
                "authors": [
                    "Wei N",
                    "Serino G",
                    "Deng XW."
                ],
                "DOI_URL": "https://doi.org/10.1016/j.tibs.2008.09.004"
            },
            "PUB00033528": {
                "PMID": 11742986,
                "ISBN": null,
                "volume": "20",
                "issue": "24",
                "year": 2001,
                "title": "Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome.",
                "URL": null,
                "raw_pages": "7096-107",
                "medline_journal": "EMBO J",
                "ISO_journal": "EMBO J.",
                "authors": [
                    "Fu H",
                    "Reis N",
                    "Lee Y",
                    "Glickman MH",
                    "Vierstra RD."
                ],
                "DOI_URL": "http://dx.doi.org/10.1093/emboj/20.24.7096"
            },
            "PUB00085267": {
                "PMID": 27342858,
                "ISBN": null,
                "volume": "113",
                "issue": "28",
                "year": 2016,
                "title": "Structure of the human 26S proteasome at a resolution of 3.9 A.",
                "URL": null,
                "raw_pages": "7816-21",
                "medline_journal": "Proc Natl Acad Sci U S A",
                "ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
                "authors": [
                    "Schweitzer A",
                    "Aufderheide A",
                    "Rudack T",
                    "Beck F",
                    "Pfeifer G",
                    "Plitzko JM",
                    "Sakata E",
                    "Schulten K",
                    "Forster F",
                    "Baumeister W."
                ],
                "DOI_URL": "https://doi.org/10.1073/pnas.1608050113"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 10865,
            "pathways": 256,
            "proteins": 10865,
            "proteomes": 3375,
            "sets": 0,
            "structural_models": {
                "alphafold": 9879,
                "bfvd": 0
            },
            "structures": 125,
            "taxa": 11216
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "4d0p",
            "name": "Crystal structure of human CSN4"
        }
    }
}