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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR039915",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0007052",
"name": "mitotic spindle organization",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"panther": {
"PTHR13924": "TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR039915",
"name": "TACC family",
"type": "Family",
"children": []
},
"name": {
"name": "TACC family",
"short": "TACC"
},
"description": [
{
"text": "<p>The TACC protein family localises to the centrosome (the spindle pole body in fungi) and mitotic spindle, and plays a crucial role in bipolar spindle assembly [[cite:PUB00086639], [cite:PUB00090303]]. Furthermore, Alp7/TACC recruits kinesin-8-PP1 to the kinetochore to regulate timely mitotic progression and chromosome movement during anaphase A [[cite:PUB00090304]].</p>\r\n\r\n<p>There is only one TACC protein in the nematode Caenorhabditis elegans (TAC-1), in Drosophila melanogaster (D-TACC), in Xenopus laevis (Maskin), and in fission yeast (Alp7 also known as Mia1p); by contrast, mammals have three TACC proteins (TACC1, TACC2 and TACC3) [[cite:PUB00086636]].</p>",
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],
"wikipedia": null,
"literature": {
"PUB00090303": {
"PMID": 17476213,
"ISBN": null,
"volume": "447",
"issue": "7142",
"year": 2007,
"title": "Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast.",
"URL": null,
"raw_pages": "334-7",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Sato M",
"Toda T."
],
"DOI_URL": "https://doi.org/10.1038/nature05773"
},
"PUB00086639": {
"PMID": 24937146,
"ISBN": null,
"volume": "588",
"issue": "17",
"year": 2014,
"title": "Targeting Alp7/TACC to the spindle pole body is essential for mitotic spindle assembly in fission yeast.",
"URL": null,
"raw_pages": "2814-21",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett.",
"authors": [
"Tang NH",
"Okada N",
"Fong CS",
"Arai K",
"Sato M",
"Toda T."
],
"DOI_URL": "https://doi.org/10.1016/j.febslet.2014.06.027"
},
"PUB00090304": {
"PMID": 25472718,
"ISBN": null,
"volume": "128",
"issue": "2",
"year": 2015,
"title": "Alp7/TACC recruits kinesin-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement.",
"URL": null,
"raw_pages": "354-63",
"medline_journal": "J Cell Sci",
"ISO_journal": "J. Cell. Sci.",
"authors": [
"Tang NH",
"Toda T."
],
"DOI_URL": "https://doi.org/10.1242/jcs.160036"
},
"PUB00086636": {
"PMID": 18656360,
"ISBN": null,
"volume": "18",
"issue": "8",
"year": 2008,
"title": "The TACC proteins: TACC-ling microtubule dynamics and centrosome function.",
"URL": null,
"raw_pages": "379-88",
"medline_journal": "Trends Cell Biol",
"ISO_journal": "Trends Cell Biol.",
"authors": [
"Peset I",
"Vernos I."
],
"DOI_URL": "https://doi.org/10.1016/j.tcb.2008.06.005"
}
},
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"matches": 6878,
"pathways": 2,
"proteins": 6878,
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"sets": 0,
"structural_models": {
"alphafold": 4911,
"bfvd": 0
},
"structures": 4,
"taxa": 4334
},
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"cross_references": {},
"is_llm": false,
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"representative_structure": null
}
}
