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{
    "metadata": {
        "accession": "IPR039722",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0000184",
                "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR13112": "UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR039722",
            "name": "Nonsense-mediated mRNA decay protein 3",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Nonsense-mediated mRNA decay protein 3",
            "short": "Upf3"
        },
        "description": [
            {
                "text": "<p>This entry includes nonsense-mediated mRNA decay protein 3 (Upf3) and its homologues. In budding yeasts, Upf3 is involved in the nonsense-mediated mRNA decay (NMD) pathway [[cite:PUB00090013]]. Human Upf3a and Upf3b are components of the exon-junction complex (EJC), which promotes nonsense-mediated mRNA decay (NMD) and regulate translation efficiency [[cite:PUB00084767]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00090013": {
                "PMID": 9032286,
                "ISBN": null,
                "volume": "17",
                "issue": "3",
                "year": 1997,
                "title": "Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway.",
                "URL": null,
                "raw_pages": "1580-94",
                "medline_journal": "Mol Cell Biol",
                "ISO_journal": "Mol. Cell. Biol.",
                "authors": [
                    "He F",
                    "Brown AH",
                    "Jacobson A."
                ],
                "DOI_URL": "https://doi.org/10.1128/MCB.17.3.1580"
            },
            "PUB00084767": {
                "PMID": 16601204,
                "ISBN": null,
                "volume": "12",
                "issue": "6",
                "year": 2006,
                "title": "Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.",
                "URL": null,
                "raw_pages": "1015-22",
                "medline_journal": "RNA",
                "ISO_journal": "RNA",
                "authors": [
                    "Kunz JB",
                    "Neu-Yilik G",
                    "Hentze MW",
                    "Kulozik AE",
                    "Gehring NH."
                ],
                "DOI_URL": "https://doi.org/10.1261/rna.12506"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 6605,
            "pathways": 13,
            "proteins": 6605,
            "proteomes": 3022,
            "sets": 0,
            "structural_models": {
                "alphafold": 5855,
                "bfvd": 0
            },
            "structures": 4,
            "taxa": 8558
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "1uw4",
            "name": "The structural basis of the interaction between nonsense mediated decay factors UPF2 and UPF3"
        }
    }
}