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{
"metadata": {
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"type": "family",
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{
"identifier": "GO:0004888",
"name": "transmembrane signaling receptor activity",
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"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0032609",
"name": "type II interferon production",
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"code": "P",
"name": "biological_process"
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},
{
"identifier": "GO:0050863",
"name": "regulation of T cell activation",
"category": {
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"name": "biological_process"
}
},
{
"identifier": "GO:2000404",
"name": "regulation of T cell migration",
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],
"source_database": "interpro",
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"PTHR35265": "LEUKOSIALIN"
}
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"accession": "IPR038829",
"name": "Leukosialin",
"type": "Family",
"children": []
},
"name": {
"name": "Leukosialin",
"short": "Leukosialin"
},
"description": [
{
"text": "<p>Leukosialin (CD43, sialophorin) is a large sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes) [[cite:PUB00088464]]. It is involved in leukocyte adhesion and migration [[cite:PUB00088465], [cite:PUB00088466]]. Leukosialin interacts with the T cell receptor (TcR) to initiate signaling events during T cell priming [[cite:PUB00088460]]. The CD43 signaling pathway induces the expression of IFN-gamma by effector CD4+ T cells (Th, helper T cells) and to a lesser extent CD8+ T cells (Tc, cytotoxic T cells) [[cite:PUB00088461]]. Besides its role in progression of the T cell differentiation program, CD43 plays a role in T cell homing from lymphoid organs to peripheral tissues [[cite:PUB00088462], [cite:PUB00088463], [cite:PUB00088467]].</p>",
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"PUB00088460": {
"PMID": 22288421,
"ISBN": null,
"volume": "1253",
"issue": null,
"year": 2012,
"title": "T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival.",
"URL": null,
"raw_pages": "58-67",
"medline_journal": "Ann N Y Acad Sci",
"ISO_journal": "Ann. N. Y. Acad. Sci.",
"authors": [
"Clark MC",
"Baum LG."
],
"DOI_URL": "https://doi.org/10.1111/j.1749-6632.2011.06304.x"
},
"PUB00088461": {
"PMID": 18036228,
"ISBN": null,
"volume": "8",
"issue": null,
"year": 2007,
"title": "CD43 signals induce Type One lineage commitment of human CD4+ T cells.",
"URL": null,
"raw_pages": "30",
"medline_journal": "BMC Immunol",
"ISO_journal": "BMC Immunol.",
"authors": [
"Ramirez-Pliego O",
"Escobar-Zarate DL",
"Rivera-Martinez GM",
"Cervantes-Badillo MG",
"Esquivel-Guadarrama FR",
"Rosas-Salgado G",
"Rosenstein Y",
"Santana MA."
],
"DOI_URL": "https://doi.org/10.1186/1471-2172-8-30"
},
"PUB00088462": {
"PMID": 9126930,
"ISBN": null,
"volume": "185",
"issue": "8",
"year": 1997,
"title": "Anti-CD43 inhibition of T cell homing.",
"URL": null,
"raw_pages": "1493-8",
"medline_journal": "J Exp Med",
"ISO_journal": "J. Exp. Med.",
"authors": [
"McEvoy LM",
"Sun H",
"Frelinger JG",
"Butcher EC."
],
"DOI_URL": "https://doi.org/10.1084/jem.185.8.1493"
},
"PUB00088463": {
"PMID": 9841931,
"ISBN": null,
"volume": "188",
"issue": "11",
"year": 1998,
"title": "The functional paradox of CD43 in leukocyte recruitment: a study using CD43-deficient mice.",
"URL": null,
"raw_pages": "2181-6",
"medline_journal": "J Exp Med",
"ISO_journal": "J. Exp. Med.",
"authors": [
"Woodman RC",
"Johnston B",
"Hickey MJ",
"Teoh D",
"Reinhardt P",
"Poon BY",
"Kubes P."
],
"DOI_URL": "https://doi.org/10.1084/jem.188.11.2181"
},
"PUB00088464": {
"PMID": 1840294,
"ISBN": null,
"volume": "1",
"issue": "4",
"year": 1991,
"title": "Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.",
"URL": null,
"raw_pages": "347-56",
"medline_journal": "Glycobiology",
"ISO_journal": "Glycobiology",
"authors": [
"Fukuda M."
],
"DOI_URL": "https://doi.org/10.1093/glycob/1.4.347"
},
"PUB00088465": {
"PMID": 9638335,
"ISBN": null,
"volume": "5",
"issue": "2",
"year": 1998,
"title": "CD43 (sialophorin, leukosialin) shedding is an initial event during neutrophil migration, which could be closely related to the spreading of adherent cells.",
"URL": null,
"raw_pages": "151-60",
"medline_journal": "Cell Adhes Commun",
"ISO_journal": "Cell Adhes. Commun.",
"authors": [
"Lopez S",
"Seveau S",
"Lesavre P",
"Robinson MK",
"Halbwachs-Mecarelli L."
],
"DOI_URL": null
},
"PUB00088466": {
"PMID": 8943391,
"ISBN": null,
"volume": "157",
"issue": "11",
"year": 1996,
"title": "Disregulated expression of CD43 (leukosialin, sialophorin) in the B cell lineage leads to immunodeficiency.",
"URL": null,
"raw_pages": "4876-84",
"medline_journal": "J Immunol",
"ISO_journal": "J. Immunol.",
"authors": [
"Ostberg JR",
"Dragone LL",
"Driskell T",
"Moynihan JA",
"Phipps R",
"Barth RK",
"Frelinger JG."
],
"DOI_URL": null
},
"PUB00088467": {
"PMID": 26700769,
"ISBN": null,
"volume": "196",
"issue": "3",
"year": 2016,
"title": "CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo.",
"URL": null,
"raw_pages": "1305-1316",
"medline_journal": "J Immunol",
"ISO_journal": "J. Immunol.",
"authors": [
"Velazquez F",
"Grodecki-Pena A",
"Knapp A",
"Salvador AM",
"Nevers T",
"Croce K",
"Alcaide P."
],
"DOI_URL": "https://doi.org/10.4049/jimmunol.1501171"
}
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