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{
"metadata": {
"accession": "IPR038505",
"entry_id": null,
"type": "homologous_superfamily",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cathgene3d": {
"G3DSA:1.25.40.490": "G3DSA:1.25.40.490"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR038505",
"name": "FANCF, C-terminal domain superfamily",
"type": "Homologous_superfamily",
"children": []
},
"name": {
"name": "FANCF, C-terminal domain superfamily",
"short": "FANCF_C_sf"
},
"description": [
{
"text": "<p>Fanconi anemia (FA) is a genomic instability syndrome caused by mutations in at least 13 distinct genes whose products function in a common DNA repair signaling pathway, the FA pathway. The FA pathway cooperates with other DNA repair proteins for resolving DNA interstrand cross-links during replication [[cite:PUB00073778]].</p>\r\n\r\n<p>Fanconi anemia group F protein (FANCF) is a component of the FA core complex [[cite:PUB00073779], [cite:PUB00042632]]. FANCF regulates its own expression by methylation at both mRNA and protein levels. Methylation-induced inactivation of FANCF has an important role on the occurrence of ovarian cancers by disrupting the FA-BRCA pathway [[cite:PUB00058153]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This entry represents the C-terminal region of the FANCF protein found in metazoa. The C-terminal domain has an helical repeat structure and is necessary for the proper assembly of the FA core complex [[cite:PUB00041761]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00073779": {
"PMID": 16357213,
"ISBN": null,
"volume": "19",
"issue": "24",
"year": 2005,
"title": "The Fanconi Anemia/BRCA pathway: new faces in the crowd.",
"URL": null,
"raw_pages": "2925-40",
"medline_journal": "Genes Dev",
"ISO_journal": "Genes Dev.",
"authors": [
"Kennedy RD",
"D'Andrea AD."
],
"DOI_URL": "http://dx.doi.org/10.1101/gad.1370505"
},
"PUB00073778": {
"PMID": 20713514,
"ISBN": null,
"volume": "24",
"issue": "16",
"year": 2010,
"title": "Expanded roles of the Fanconi anemia pathway in preserving genomic stability.",
"URL": null,
"raw_pages": "1680-94",
"medline_journal": "Genes Dev",
"ISO_journal": "Genes Dev.",
"authors": [
"Kee Y",
"D'Andrea AD."
],
"DOI_URL": "http://dx.doi.org/10.1101/gad.1955310"
},
"PUB00058153": {
"PMID": 16418574,
"ISBN": null,
"volume": "5",
"issue": "3",
"year": 2006,
"title": "Promoter hypermethylation of FANCF plays an important role in the occurrence of ovarian cancer through disrupting Fanconi anemia-BRCA pathway.",
"URL": null,
"raw_pages": "256-60",
"medline_journal": "Cancer Biol Ther",
"ISO_journal": "Cancer Biol. Ther.",
"authors": [
"Wang Z",
"Li M",
"Lu S",
"Zhang Y",
"Wang H."
],
"DOI_URL": null
},
"PUB00042632": {
"PMID": 17768402,
"ISBN": null,
"volume": "8",
"issue": "10",
"year": 2007,
"title": "Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.",
"URL": null,
"raw_pages": "735-48",
"medline_journal": "Nat Rev Genet",
"ISO_journal": "Nat. Rev. Genet.",
"authors": [
"Wang W."
],
"DOI_URL": "http://dx.doi.org/10.1038/nrg2159"
},
"PUB00041761": {
"PMID": 17082180,
"ISBN": null,
"volume": "282",
"issue": "3",
"year": 2007,
"title": "Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex.",
"URL": null,
"raw_pages": "2047-55",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Kowal P",
"Gurtan AM",
"Stuckert P",
"D'Andrea AD",
"Ellenberger T."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M608356200"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR035428",
"name": "Fanconi anemia group F protein",
"type": "family"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 643,
"pathways": 4,
"proteins": 642,
"proteomes": 531,
"sets": 0,
"structural_models": {
"alphafold": 561,
"bfvd": 0
},
"structures": 7,
"taxa": 1934
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
