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{
    "metadata": {
        "accession": "IPR038466",
        "entry_id": null,
        "type": "homologous_superfamily",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "cathgene3d": {
                "G3DSA:3.30.70.850": "Peptidase S8, pro-domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR038466",
            "name": "Peptidase S8, pro-domain superfamily",
            "type": "Homologous_superfamily",
            "children": []
        },
        "name": {
            "name": "Peptidase S8, pro-domain superfamily",
            "short": "S8_pro-domain_sf"
        },
        "description": [
            {
                "text": "<p>This domain is the pro-domain found at the C terminus of several peptidases belonging to family S8 [[cite:PUB00011744]]. The overall fold of the PC1 pro-domain consists of two α-helices and four β-strands in a β-α-β-β-α-β arrangement.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00011744": {
                "PMID": 12095256,
                "ISBN": null,
                "volume": "320",
                "issue": "4",
                "year": 2002,
                "title": "Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculus.",
                "URL": null,
                "raw_pages": "801-12",
                "medline_journal": "J Mol Biol",
                "ISO_journal": "J. Mol. Biol.",
                "authors": [
                    "Tangrea MA",
                    "Bryan PN",
                    "Sari N",
                    "Orban J."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/S0022-2836(02)00543-0"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR032815",
                "name": "Peptidase S8, pro-domain",
                "type": "domain"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 11540,
            "pathways": 62,
            "proteins": 11505,
            "proteomes": 1280,
            "sets": 0,
            "structural_models": {
                "alphafold": 9634,
                "bfvd": 0
            },
            "structures": 4,
            "taxa": 4474
        },
        "entry_annotations": {},
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "3.4.21",
                        "url": "https://enzyme.expasy.org/EC/3.4.21"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "9fic",
            "name": "High-resolution X-ray structure of human PC1/3 (PCSK1) prodomain R77A,R80A,R81A triple-mutant"
        }
    }
}