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{
"metadata": {
"accession": "IPR038083",
"entry_id": null,
"type": "homologous_superfamily",
"go_terms": [
{
"identifier": "GO:0003727",
"name": "single-stranded RNA binding",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"ssf": {
"SSF159936": "NSP3A-like"
},
"cathgene3d": {
"G3DSA:3.10.20.350": "G3DSA:3.10.20.350"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR038083",
"name": "Non-structural protein NSP3A domain-like superfamily",
"type": "Homologous_superfamily",
"children": []
},
"name": {
"name": "Non-structural protein NSP3A domain-like superfamily",
"short": "NSP3A-like"
},
"description": [
{
"text": "<p>The multi-domain non-structural protein NSP3 is the largest protein encoded by the coronavirus (CoV) genome, with an average molecular mass of about 200 kD. While some of the domains differ between CoV genera, eight domains of NSP3 exist in all known CoVs: the ubiquitin-like domain 1 (Ubl1), the Glu-rich acidic domain (also called \"hypervariable region\"), a macrodomain (also named \"X domain\"), the ubiquitin-like domain 2 (Ubl2), the papain-like protease 2 (PL2pro), the NSP3 ectodomain (3Ecto, also called \"zinc-finger domain\"), as well as the domains Y1 and CoV-Y of unknown functions. There are also two transmembrane regions, TM1 and TM2, which exist in all CoVs [[cite:PUB00094069]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>The ubiquitin-like domain 1 (Ubl1) and the Glu-rich acidic region are located at the N-terminal of NSP3. These two regions together are also named \"NSP3A\". In addition to the four β-strands and two α-helices that are common to ubiquitin-like folds, the globular domain of NSP3A contains two short helices [[cite:PUB00094069]]. NSP3A is well conserved within different SARS-CoV sequences but exhibits low sequence identity (less than 35%) to other CoV NSP3 proteins [[cite:PUB00047544]]. It is an essential component of the replication/transcription complex and is involved in multiple biological processes, such as proteolysis and RNA processing [[cite:PUB00094069]].</p>\n\n<p>This entry represents NSP3A that has been shown to bind ssRNA. The overall structure of the SARS-CoV Ubl1 domain is similar to human ubiquitin (Ub) and that of each of the two ubiquitin-like domains of human or mouse interferon-stimulated gene 15 (hISG15 or mISG15). It is also similar to the Ras-interacting domain (RID) of RalGDS [[cite:PUB00047544], [cite:PUB00094069]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00047544": {
"PMID": 17728234,
"ISBN": null,
"volume": "81",
"issue": "21",
"year": 2007,
"title": "Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus.",
"URL": null,
"raw_pages": "12049-60",
"medline_journal": "J Virol",
"ISO_journal": "J. Virol.",
"authors": [
"Serrano P",
"Johnson MA",
"Almeida MS",
"Horst R",
"Herrmann T",
"Joseph JS",
"Neuman BW",
"Subramanian V",
"Saikatendu KS",
"Buchmeier MJ",
"Stevens RC",
"Kuhn P",
"Wuthrich K."
],
"DOI_URL": "http://dx.doi.org/10.1128/JVI.00969-07"
},
"PUB00094069": {
"PMID": 29128390,
"ISBN": null,
"volume": "149",
"issue": null,
"year": 2018,
"title": "Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.",
"URL": null,
"raw_pages": "58-74",
"medline_journal": "Antiviral Res",
"ISO_journal": "Antiviral Res.",
"authors": [
"Lei J",
"Kusov Y",
"Hilgenfeld R."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR044357",
"name": "NSP3, first ubiquitin-like (Ubl) domain, coronavirus",
"type": "domain"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 1,
"matches": 5538,
"pathways": 17,
"proteins": 5538,
"proteomes": 17,
"sets": 0,
"structural_models": {
"alphafold": 0,
"bfvd": 4
},
"structures": 12,
"taxa": 281
},
"entry_annotations": {},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "2.7.7.50",
"url": "https://enzyme.expasy.org/EC/2.7.7.50"
},
{
"accession": "3.4.19.12",
"url": "https://enzyme.expasy.org/EC/3.4.19.12"
},
{
"accession": "3.4.22.-",
"url": "https://enzyme.expasy.org/EC/3.4.22.-"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "8hda",
"name": "Crystal structure of Ubl1 (residues 18-111) of SARS-CoV-2"
}
}
}
