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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR037620",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd09562": "SAM domain of liprin-alpha1,2,3,4 proteins repeat 1"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001660",
"name": "Sterile alpha motif domain",
"type": "Domain",
"children": [
{
"accession": "IPR030602",
"name": "Ephrin type-A receptor 4, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035497",
"name": "Caskin1/2, SAM repeat 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035498",
"name": "Caskin1/2, SAM repeat 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR037601",
"name": "ANKS4B, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037602",
"name": "USH1G, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037603",
"name": "SEC23-interacting protein, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037604",
"name": "Scm-like with four MBT domains protein 1/2, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037605",
"name": "Sfmbt, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037606",
"name": "Diacylglycerol kinase delta, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037609",
"name": "Stromal interaction molecule 1, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037610",
"name": "Stromal interaction molecule 2, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037611",
"name": "Tumour protein p63, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037612",
"name": "Tumour protein p73, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037613",
"name": "Kazrin, SAM domain repeat 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR037615",
"name": "Kazrin, SAM domain repeat 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR037616",
"name": "Kazrin, SAM domain repeat 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR037617",
"name": "Liprin-beta-1/2, SAM domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR037618",
"name": "Liprin-beta-1/2, SAM domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR037619",
"name": "Liprin-beta-1/2, SAM domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR037620",
"name": "Liprin-alpha, SAM domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR037621",
"name": "Liprin-alpha, SAM domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR037622",
"name": "Liprin-alpha, SAM domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR037623",
"name": "SAMSN1, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037627",
"name": "SASH1, SAM domain repeat 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR037630",
"name": "SASH1, SAM domain repeat 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR037634",
"name": "Protein Smaug, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037635",
"name": "VTS1, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037636",
"name": "EPH-B4, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037974",
"name": "BICC1, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR039144",
"name": "Aveugle-like, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041880",
"name": "Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR041882",
"name": "Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR042650",
"name": "ASZ1, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042746",
"name": "EPH-A6 , SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042813",
"name": "SAMD3, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042819",
"name": "EphB1 , SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047238",
"name": "Ankyrin repeat and SAM domain-containing protein 3, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047531",
"name": "Sex comb on midleg-like, SAM domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR049628",
"name": "CNK1-3, SAM domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Liprin-alpha, SAM domain 1",
"short": "LIP-1_SAM_1"
},
"description": [
{
"text": "<p>This entry represents the SAM (sterile alpha motif) domain repeat 1 of liprin-alpha.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Liprin-alpha proteins contain three copies (repeats) of the SAM domain, which is a protein-protein interaction domain. They may form heterodimers with liprin-beta proteins through their SAM domains ([interpro:IPR037620], [interpro:IPR037621], [interpro:IPR037622]). They participate in mammary gland development and in axon guidance; in particular, liprin-alpha is involved in formation of the presynaptic active zone [[cite:PUB00072821], [cite:PUB00072887]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00072821": {
"PMID": 9624153,
"ISBN": null,
"volume": "273",
"issue": "25",
"year": 1998,
"title": "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.",
"URL": null,
"raw_pages": "15611-20",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Serra-Pages C",
"Medley QG",
"Tang M",
"Hart A",
"Streuli M."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.273.25.15611"
},
"PUB00072887": {
"PMID": 17956329,
"ISBN": null,
"volume": "35",
"issue": "Pt 5",
"year": 2007,
"title": "Liprin-alpha proteins: scaffold molecules for synapse maturation.",
"URL": null,
"raw_pages": "1278-82",
"medline_journal": "Biochem Soc Trans",
"ISO_journal": "Biochem. Soc. Trans.",
"authors": [
"Spangler SA",
"Hoogenraad CC."
],
"DOI_URL": "http://dx.doi.org/10.1042/BST0351278"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR013761",
"name": "Sterile alpha motif/pointed domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 8569,
"pathways": 24,
"proteins": 8568,
"proteomes": 1155,
"sets": 0,
"structural_models": {
"alphafold": 7213,
"bfvd": 0
},
"structures": 4,
"taxa": 3932
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
