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{
    "metadata": {
        "accession": "IPR037445",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR11736": "MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR037445",
            "name": "Melanoma-associated antigen",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Melanoma-associated antigen",
            "short": "MAGE"
        },
        "description": [
            {
                "text": "<p>The melanoma antigen (MAGE) protein family contains more than 25 members that share a conserved MAGE homology domain (MHD) [[cite:PUB00007179]].</p>\n\n<p>Proteins known to contain a MAGE domain are listed below:</p>\n\n<ul><li>Human MAGE-A, -B and -C proteins. MAGE-A, -B and -C genes are silent in all normal tissues with the exception of testis.</li>\n<li>Human MAGE-D to -L proteins. MAGE-D to -L genes are expressed in normal adult tissues.</li>\n<li>Mouse Mage-a and -b proteins.</li>\n<li>Mouse Mage-d, -e, -g, -h, -k and -l.</li>\n<li>Mammalian Necdin. The human Necdin gene is a candidate for the Prader-Willi syndrome.</li>\n<li>Human Trophinin mediates apical cell adhesion between trophoblastic cells and luminal epithelial cells of the endometrium and is implicated in the initial attachment during the process of human embryo implantation [[cite:PUB00153028]].</li></ul>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00007179": {
                "PMID": 11454705,
                "ISBN": null,
                "volume": "61",
                "issue": "14",
                "year": 2001,
                "title": "An overview of the MAGE gene family with the identification of all human members of the family.",
                "URL": null,
                "raw_pages": "5544-51",
                "medline_journal": "Cancer Res",
                "ISO_journal": "Cancer Res.",
                "authors": [
                    "Chomez P",
                    "De Backer O",
                    "Bertrand M",
                    "De Plaen E",
                    "Boon T",
                    "Lucas S."
                ],
                "DOI_URL": "http://cancerres.aacrjournals.org/cgi/content/abstract/61/14/5544"
            },
            "PUB00153028": {
                "PMID": 11590179,
                "ISBN": null,
                "volume": "276",
                "issue": "52",
                "year": 2001,
                "title": "The trophinin gene encodes a novel group of MAGE proteins, magphinins, and regulates cell proliferation during gametogenesis in the mouse.",
                "URL": null,
                "raw_pages": "49378-89",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J Biol Chem",
                "authors": [
                    "Saburi S",
                    "Nadano D",
                    "Akama TO",
                    "Hirama K",
                    "Yamanouchi K",
                    "Naito K",
                    "Tojo H",
                    "Tachi C",
                    "Fukuda MN."
                ],
                "DOI_URL": "https://doi.org/10.1074/jbc.M108584200"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR041898",
                "name": "MAGE homology domain, winged helix WH1 motif",
                "type": "homologous_superfamily"
            },
            {
                "accession": "IPR041899",
                "name": "MAGE homology domain, winged helix WH2 motif",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 10073,
            "pathways": 14,
            "proteins": 10073,
            "proteomes": 2677,
            "sets": 0,
            "structural_models": {
                "alphafold": 8346,
                "bfvd": 0
            },
            "structures": 18,
            "taxa": 7754
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "7dg2",
            "name": "Nse1-Nse3-Nse4 complex"
        }
    }
}