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{
"metadata": {
"accession": "IPR037307",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0007250",
"name": "activation of NF-kappaB-inducing kinase activity",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0046330",
"name": "positive regulation of JNK cascade",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd03781": "MATH_TRAF4"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR002083",
"name": "MATH/TRAF domain",
"type": "Domain",
"children": [
{
"accession": "IPR037299",
"name": "TRIM37, MATH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR049342",
"name": "TRAF1-6, MATH domain",
"type": "Domain",
"children": [
{
"accession": "IPR037304",
"name": "TNF receptor-associated factor 3, MATH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037305",
"name": "TNF receptor-associated factor 2, MATH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037306",
"name": "TNF receptor-associated factor 1, MATH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037307",
"name": "TNF receptor-associated factor 4, MATH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037309",
"name": "TNF receptor-associated factor 6, MATH domain",
"type": "Domain",
"children": []
}
]
}
]
},
"name": {
"name": "TNF receptor-associated factor 4, MATH domain",
"short": "TRAF4_MATH"
},
"description": [
{
"text": "<p>TNF receptor-associated factor 4 (TRAF4) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. TRAF4 plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. It regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. TRAF4 modulates TRAF6 functions [[cite:PUB00063013], [cite:PUB00063014], [cite:PUB00063015], [cite:PUB00063016], [cite:PUB00063018], [cite:PUB00063019]]. In mouse, it has been shown to be required for normal skeleton development, and for normal development of the respiratory tract [[cite:PUB00063017]]. TRAF4 contains a RING finger domain, seven zinc finger domains, and a TRAF domain.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>The TRAF domain can be divided into a more divergent N-terminal α helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded β-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [[cite:PUB00011816], [cite:PUB00011815]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00063019": {
"PMID": 19937093,
"ISBN": null,
"volume": "338",
"issue": "1-2",
"year": 2010,
"title": "Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation.",
"URL": null,
"raw_pages": "11-7",
"medline_journal": "Mol Cell Biochem",
"ISO_journal": "Mol. Cell. Biochem.",
"authors": [
"Li S",
"Lu K",
"Wang J",
"An L",
"Yang G",
"Chen H",
"Cui Y",
"Yin X",
"Xie P",
"Xing G",
"He F",
"Zhang L."
],
"DOI_URL": "http://dx.doi.org/10.1007/s11010-009-0315-y"
},
"PUB00063015": {
"PMID": 16052631,
"ISBN": null,
"volume": "35",
"issue": "8",
"year": 2005,
"title": "TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.",
"URL": null,
"raw_pages": "2477-85",
"medline_journal": "Eur J Immunol",
"ISO_journal": "Eur. J. Immunol.",
"authors": [
"Takeshita F",
"Ishii KJ",
"Kobiyama K",
"Kojima Y",
"Coban C",
"Sasaki S",
"Ishii N",
"Klinman DM",
"Okuda K",
"Akira S",
"Suzuki K."
],
"DOI_URL": "http://dx.doi.org/10.1002/eji.200526151"
},
"PUB00063016": {
"PMID": 16157600,
"ISBN": null,
"volume": "280",
"issue": "43",
"year": 2005,
"title": "MEKK4 is an effector of the embryonic TRAF4 for JNK activation.",
"URL": null,
"raw_pages": "35793-6",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Abell AN",
"Johnson GL."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.C500260200"
},
"PUB00063017": {
"PMID": 10934170,
"ISBN": null,
"volume": "157",
"issue": "2",
"year": 2000,
"title": "TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs.",
"URL": null,
"raw_pages": "679-88",
"medline_journal": "Am J Pathol",
"ISO_journal": "Am. J. Pathol.",
"authors": [
"Shiels H",
"Li X",
"Schumacker PT",
"Maltepe E",
"Padrid PA",
"Sperling A",
"Thompson CB",
"Lindsten T."
],
"DOI_URL": null
},
"PUB00063018": {
"PMID": 18953416,
"ISBN": null,
"volume": "3",
"issue": "10",
"year": 2008,
"title": "Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis.",
"URL": null,
"raw_pages": "e3518",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS ONE",
"authors": [
"Kedinger V",
"Alpy F",
"Baguet A",
"Polette M",
"Stoll I",
"Chenard MP",
"Tomasetto C",
"Rio MC."
],
"DOI_URL": "http://dx.doi.org/10.1371/journal.pone.0003518"
},
"PUB00011815": {
"PMID": 10518213,
"ISBN": null,
"volume": "4",
"issue": "3",
"year": 1999,
"title": "The structural basis for the recognition of diverse receptor sequences by TRAF2.",
"URL": null,
"raw_pages": "321-30",
"medline_journal": "Mol Cell",
"ISO_journal": "Mol. Cell",
"authors": [
"Ye H",
"Park YC",
"Kreishman M",
"Kieff E",
"Wu H."
],
"DOI_URL": "http://dx.doi.org/10.1016/S1097-2765(00)80334-2"
},
"PUB00063013": {
"PMID": 12023963,
"ISBN": null,
"volume": "277",
"issue": "31",
"year": 2002,
"title": "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase.",
"URL": null,
"raw_pages": "28051-7",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Xu YC",
"Wu RF",
"Gu Y",
"Yang YS",
"Yang MC",
"Nwariaku FE",
"Terada LS."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M202665200"
},
"PUB00011816": {
"PMID": 10206649,
"ISBN": null,
"volume": "398",
"issue": "6727",
"year": 1999,
"title": "Structural basis for self-association and receptor recognition of human TRAF2.",
"URL": null,
"raw_pages": "533-8",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Park YC",
"Burkitt V",
"Villa AR",
"Tong L",
"Wu H."
],
"DOI_URL": "http://dx.doi.org/10.1038/19110"
},
"PUB00063014": {
"PMID": 12801526,
"ISBN": null,
"volume": "27",
"issue": "8",
"year": 2003,
"title": "Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase.",
"URL": null,
"raw_pages": "687-94",
"medline_journal": "Leuk Res",
"ISO_journal": "Leuk. Res.",
"authors": [
"Fleckenstein DS",
"Dirks WG",
"Drexler HG",
"Quentmeier H."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0145-2126(02)00325-9"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR008974",
"name": "TRAF-like",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 896,
"pathways": 0,
"proteins": 896,
"proteomes": 663,
"sets": 0,
"structural_models": {
"alphafold": 827,
"bfvd": 0
},
"structures": 7,
"taxa": 2105
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "3zjb",
"name": "The structure of the TRAF domain of human TRAF4"
}
}
}
