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{
    "metadata": {
        "accession": "IPR037158",
        "entry_id": null,
        "type": "homologous_superfamily",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "cathgene3d": {
                "G3DSA:3.90.1380.10": "Threonine synthase, N-terminal domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR037158",
            "name": "Threonine synthase, N-terminal domain superfamily",
            "type": "Homologous_superfamily",
            "children": []
        },
        "name": {
            "name": "Threonine synthase, N-terminal domain superfamily",
            "short": "Thr_synth_N_sf"
        },
        "description": [
            {
                "text": "<p>This domain superfamily is found at the N terminus of many threonine synthase enzymes [[cite:PUB00026749]]. Threonine synthases catalyses the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine [[cite:PUB00070206]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00026749": {
                "PMID": 11756443,
                "ISBN": null,
                "volume": "277",
                "issue": "14",
                "year": 2002,
                "title": "Structure and function of threonine synthase from yeast.",
                "URL": null,
                "raw_pages": "12396-405",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Garrido-Franco M",
                    "Ehlert S",
                    "Messerschmidt A",
                    "Marinkovic' S",
                    "Huber R",
                    "Laber B",
                    "Bourenkov GP",
                    "Clausen T."
                ],
                "DOI_URL": "http://dx.doi.org/10.1074/jbc.M108734200"
            },
            "PUB00070206": {
                "PMID": 8074505,
                "ISBN": null,
                "volume": "60",
                "issue": "7",
                "year": 1994,
                "title": "Analysis and expression of the thrC gene of Brevibacterium lactofermentum and characterization of the encoded threonine synthase.",
                "URL": null,
                "raw_pages": "2209-19",
                "medline_journal": "Appl Environ Microbiol",
                "ISO_journal": "Appl. Environ. Microbiol.",
                "authors": [
                    "Malumbres M",
                    "Mateos LM",
                    "Lumbreras MA",
                    "Guerrero C",
                    "Martin JF."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR036052",
                "name": "Tryptophan synthase beta chain-like, PALP domain superfamily",
                "type": "homologous_superfamily"
            },
            {
                "accession": "IPR029144",
                "name": "Threonine synthase, N-terminal",
                "type": "domain"
            },
            {
                "accession": "IPR051166",
                "name": "Threonine Synthase",
                "type": "family"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 20321,
            "pathways": 0,
            "proteins": 20318,
            "proteomes": 12411,
            "sets": 0,
            "structural_models": {
                "alphafold": 16443,
                "bfvd": 0
            },
            "structures": 5,
            "taxa": 22724
        },
        "entry_annotations": {},
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "4.2.3.1",
                        "url": "https://enzyme.expasy.org/EC/4.2.3.1"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}