HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "IPR036877",
"entry_id": null,
"type": "homologous_superfamily",
"go_terms": [
{
"identifier": "GO:0003743",
"name": "translation initiation factor activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006413",
"name": "translational initiation",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"ssf": {
"SSF55159": "eIF1-like"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR036877",
"name": "SUI1 domain superfamily",
"type": "Homologous_superfamily",
"children": []
},
"name": {
"name": "SUI1 domain superfamily",
"short": "SUI1_dom_sf"
},
"description": [
{
"text": "<p>In budding yeast (Saccharomyces cerevisiae), SUI1 is a translation initiation factor that functions in concert with eIF-2 and the initiator tRNA-Met in directing the ribosome to the proper start site of translation [[cite:PUB00003679]]. SUI1 is a protein of 108 residues. Close homologues of SUI1 have been found [[cite:PUB00000232]] in mammals, insects and plants. SUI1 is also evolutionary related to:</p>\n\n<ul>\n<li>Hypothetical proteins from bacteria such as Escherichia coli (YciH) or Haemophilus influenzae (HI1225).</li>\n<li>Hypothetical proteins from archaea such as Methanococcus jannaschii (MJ0463).</li>\n</ul>\n\n<p>Two eukaryotic proteins also seem to contain a C-terminal SUI1-like domain. These are:</p>\n\n<ul>\n<li>Density-regulated protein (gene: DENR). This protein is found in mammals, insects, nematodes, plants and fungi.</li>\n<li>Ligatin (gene: LGTN). This protein is found in mammals and insects.</li>\n</ul>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00003679": {
"PMID": 1729602,
"ISBN": null,
"volume": "12",
"issue": "1",
"year": 1992,
"title": "The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon.",
"URL": null,
"raw_pages": "248-60",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Yoon HJ",
"Donahue TF."
],
"DOI_URL": "http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=1729602"
},
"PUB00000232": {
"PMID": 7904817,
"ISBN": null,
"volume": "198",
"issue": "1",
"year": 1994,
"title": "Expressed sequence tags identify a human isolog of the suil translation initiation factor.",
"URL": null,
"raw_pages": "288-91",
"medline_journal": "Biochem Biophys Res Commun",
"ISO_journal": "Biochem. Biophys. Res. Commun.",
"authors": [
"Fields C",
"Adams MD."
],
"DOI_URL": "http://dx.doi.org/10.1006/bbrc.1994.1040"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR001950",
"name": "SUI1 domain",
"type": "domain"
},
{
"accession": "IPR005874",
"name": "Eukaryotic translation initiation factor SUI1",
"type": "family"
},
{
"accession": "IPR005872",
"name": "Archaeal/bacterial translation initiation factor SUI1",
"type": "family"
},
{
"accession": "IPR005873",
"name": "DENR, eukaryotes",
"type": "family"
},
{
"accession": "IPR022851",
"name": "Translation factor SUI1 homolog, archaea",
"type": "family"
},
{
"accession": "IPR050318",
"name": "DENR/SUI1 Translation Initiation Factor",
"type": "family"
},
{
"accession": "IPR048517",
"name": "DENR, N-terminal domain",
"type": "domain"
},
{
"accession": "IPR046447",
"name": "DENR, C-terminal domain",
"type": "domain"
},
{
"accession": "IPR039759",
"name": "Eukaryotic translation initiation factor 2D, SUI1 domain",
"type": "domain"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 25241,
"pathways": 0,
"proteins": 25152,
"proteomes": 9002,
"sets": 0,
"structural_models": {
"alphafold": 21657,
"bfvd": 8
},
"structures": 43,
"taxa": 20106
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "5zcy",
"name": "Crystal structure of archaeal translation initiation factor 1 at 1.5 Angstroms resolution"
}
}
}
