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{
"metadata": {
"accession": "IPR036260",
"entry_id": null,
"type": "homologous_superfamily",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"ssf": {
"SSF101399": "P40 nucleoprotein"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR036260",
"name": "P40 nucleoprotein superfamily, Borna disease virus",
"type": "Homologous_superfamily",
"children": []
},
"name": {
"name": "P40 nucleoprotein superfamily, Borna disease virus",
"short": "P40_nucleoprot_sf_BD-vir"
},
"description": [
{
"text": "<p>This entry represents P40 nucleoproteins from several Borna disease virus (BDV) strains. BDV is an RNA virus that is a member of the Mononegavirales family, which includes such members as Measles virus and Ebola virus sp.. BDV causes an infection of the central nervous system in a wide range of vertebrates, which can progress to an often fatal immune-mediated disease. Viral nucleoproteins are central to transcription, replication, and packaging of the RNA genome. P40 nucleoprotein from BDV is multi-helical in structure and can be divided into two subdomains, each of which has an α-bundle topology [[cite:PUB00012372]]. The nucleoprotein assembles into a planar homotetramer, with the RNA genome either wrapping around the outside of the tetramer or possibly fitting within the charged central channel of the tetramer [[cite:PUB00029014]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00012372": {
"PMID": 9882386,
"ISBN": null,
"volume": "73",
"issue": "2",
"year": 1999,
"title": "Borna disease virus nucleoprotein (p40) is a major target for CD8(+)-T-cell-mediated immune response.",
"URL": null,
"raw_pages": "1715-8",
"medline_journal": "J Virol",
"ISO_journal": "J. Virol.",
"authors": [
"Planz O",
"Stitz L."
],
"DOI_URL": "http://jvi.asm.org/cgi/content/abstract/73/2/1715"
},
"PUB00029014": {
"PMID": 14527390,
"ISBN": null,
"volume": "11",
"issue": "10",
"year": 2003,
"title": "Crystal structure of the borna disease virus nucleoprotein.",
"URL": null,
"raw_pages": "1219-26",
"medline_journal": "Structure",
"ISO_journal": "Structure",
"authors": [
"Rudolph MG",
"Kraus I",
"Dickmanns A",
"Eickmann M",
"Garten W",
"Ficner R."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.str.2003.08.011"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR015969",
"name": "P40 nucleoprotein, subdomain 1, Borna disease virus",
"type": "homologous_superfamily"
},
{
"accession": "IPR009441",
"name": "P40 nucleoprotein, Borna disease virus",
"type": "family"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 497,
"pathways": 0,
"proteins": 497,
"proteomes": 55,
"sets": 0,
"structural_models": {
"alphafold": 51,
"bfvd": 15
},
"structures": 2,
"taxa": 306
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "1n93",
"name": "Crystal Structure of the Borna Disease Virus Nucleoprotein"
}
}
}
