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{
"metadata": {
"accession": "IPR035770",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd12052": "First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001452",
"name": "SH3 domain",
"type": "Domain",
"children": [
{
"accession": "IPR028455",
"name": "ABI gene family member 3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR028503",
"name": "Endophilin-B1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR028570",
"name": "Kalirin/Triple functional domain protein, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR029294",
"name": "Helically-extended SH3 domain",
"type": "Domain",
"children": [
{
"accession": "IPR035540",
"name": "FYB, helically extended SH3 domain",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR030642",
"name": "Nephrocystin-1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR030777",
"name": "PSTPIP1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034889",
"name": "Neutrophil cytosol factor 2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035449",
"name": "SH3PXD2A, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035450",
"name": "SH3PXD2A, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035452",
"name": "SH3PXD2A, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035453",
"name": "SH3PXD2A, SH3 domain 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR035454",
"name": "SH3PXD2A, SH3 domain 5",
"type": "Domain",
"children": []
},
{
"accession": "IPR035456",
"name": "SH3BP4, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035457",
"name": "CRK, N-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035458",
"name": "CRK, C-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035460",
"name": "FCHSD, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035462",
"name": "Eps8, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035465",
"name": "Rho GTPase-activating protein 9, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035468",
"name": "SH3D21, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035470",
"name": "Amphiphysin I, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035471",
"name": "Amphiphysin 2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035473",
"name": "CASK, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035475",
"name": "MPP1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035477",
"name": "SH3PXD2B, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035478",
"name": "SH3PXD2B, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035479",
"name": "SH3PXD2B, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035480",
"name": "SH3PXD2B, SH3 domain 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR035481",
"name": "GRAF, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035485",
"name": "GRAF2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035489",
"name": "MYO15B, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035491",
"name": "ARHGAP12, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035492",
"name": "FNBP1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035493",
"name": "FNBP1L, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035495",
"name": "Caskin-1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035499",
"name": "Caskin2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035507",
"name": "Unconventional myosin-Ie/If, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035508",
"name": "STAC1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035509",
"name": "Stac2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035511",
"name": "SH3YL1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035514",
"name": "SPIN90, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035521",
"name": "Fus1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035522",
"name": "Sho1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035526",
"name": "Obscurin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035532",
"name": "DBS, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035535",
"name": "Fungal myosin-I, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035541",
"name": "Neutrophil cytosol factor P40, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035546",
"name": "Neutrophil cytosol factor 2, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035548",
"name": "Bem1/Scd2, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035549",
"name": "Bem1/Scd2, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035551",
"name": "Boi1/2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035552",
"name": "Mti1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035553",
"name": "Cytokinesis protein 3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035554",
"name": "Otoraplin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035555",
"name": "MIA2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035556",
"name": "FCHSD2, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035557",
"name": "Sorting nexin-18, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035558",
"name": "SNX9, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035559",
"name": "Nck2, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035560",
"name": "Nck2, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035561",
"name": "Nck2, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035562",
"name": "Nck1, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035564",
"name": "Nck1, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035565",
"name": "Nck1, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035572",
"name": "Tyrosine-protein kinase Tec, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035574",
"name": "Tyrosine-protein kinase BTK, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035579",
"name": "Tyrosine-protein kinase TXK, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035583",
"name": "Tyrosine-protein kinase ITK, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035586",
"name": "Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035591",
"name": "Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035592",
"name": "IRTKS, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035593",
"name": "Pinkbar, SH3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035594",
"name": "BAR/IMD domain-containing adapter protein 2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035596",
"name": "Src-like-adapter, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035597",
"name": "ZO-1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035598",
"name": "ZO-2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035599",
"name": "MPP7, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035600",
"name": "MPP4, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035601",
"name": "MPP5, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035602",
"name": "MPP2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035603",
"name": "MPP6, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035604",
"name": "MPP3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035605",
"name": "CACNB2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035606",
"name": "Sorbin and SH3 domain-containing protein 1, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035607",
"name": "Vinexin, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035608",
"name": "Vinexin, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035609",
"name": "Vinexin, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035610",
"name": "Sorbin and SH3 domain-containing protein 1, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035611",
"name": "Sorbin and SH3 domain-containing protein 1, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035612",
"name": "SH3RF3, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035629",
"name": "Nebulin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035630",
"name": "Lasp1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035631",
"name": "Nebulette, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035632",
"name": "UBASH3B, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035634",
"name": "UBASH3A, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035635",
"name": "Ephexin-1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035636",
"name": "ARHGEF37, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035637",
"name": "JIP2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035638",
"name": "JIP1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035640",
"name": "Endophilin B2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035641",
"name": "GRB2, N-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035643",
"name": "GRB2, C-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035645",
"name": "GRAP, N-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035646",
"name": "GRAP2, C-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035648",
"name": "srGAP1/2/3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035652",
"name": "RasGAP, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035653",
"name": "Alpha-(1,6)-fucosyltransferase, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035656",
"name": "Nostrin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035657",
"name": "STAM1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035675",
"name": "STAM2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035677",
"name": "ASAP2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035678",
"name": "srGAP4, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035716",
"name": "Cortactin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035717",
"name": "Drebrin-like protein, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035718",
"name": "Fungal actin-binding protein 1, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035719",
"name": "Fungal actin-binding protein 1, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035720",
"name": "SAM and SH3 domain-containing protein 1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035721",
"name": "SAM and SH3 domain-containing protein 3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035723",
"name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035724",
"name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035725",
"name": "Abl Interactor 1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035726",
"name": "Abl interactor 2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035728",
"name": "Rho guanine nucleotide exchange factor 9, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035729",
"name": "VAV1 protein, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035732",
"name": "VAV2 protein, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035733",
"name": "VAV2 protein, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035734",
"name": "VAV3 protein, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035735",
"name": "Shank1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035736",
"name": "Stac3, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035737",
"name": "Intersectin-2, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035738",
"name": "Intersectin-2, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035739",
"name": "Intersectin-2, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035740",
"name": "Intersectin-2, fourth SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035741",
"name": "Intersectin-2, fifth SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035743",
"name": "PACSIN1/PACSIN2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035744",
"name": "Cas scaffolding protein family member 4, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035745",
"name": "BCAR1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035746",
"name": "Enhancer of filamentation 1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035747",
"name": "Embryonal Fyn-associated substrate, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035748",
"name": "Tyrosine-protein kinase Lyn, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035749",
"name": "Lck, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035750",
"name": "Fyn/Yrk, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035751",
"name": "Tyrosine-protein kinase Yes, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035753",
"name": "RIMS-binding protein, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035755",
"name": "RIMS-binding protein, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035756",
"name": "Neutrophil cytosol factor 1, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035757",
"name": "Neutrophil cytosol factor 1, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035758",
"name": "NADPH oxidase organiser 1, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035759",
"name": "Disks Large homologue 2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035760",
"name": "Voltage-dependent L-type calcium channel subunit beta-3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035763",
"name": "Disks Large homologue 3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035765",
"name": "Src kinase-associated phosphoprotein 1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035767",
"name": "Dedicator of cytokinesis 3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035769",
"name": "Dedicator of cytokinesis 4, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035770",
"name": "SH3 domain-containing kinase-binding protein 1, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035771",
"name": "SH3 domain-containing kinase-binding protein 1, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035772",
"name": "SH3 domain-containing kinase-binding protein 1, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035775",
"name": "CD2-associated protein, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035776",
"name": "CD2-associated protein, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035777",
"name": "CD2-associated protein, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035779",
"name": "MLK1-3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035788",
"name": "Rho guanine nucleotide exchange factor 6, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035789",
"name": "Rho guanine nucleotide exchange factor 7, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035792",
"name": "E3 ubiquitin-protein ligase SH3RF2, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035794",
"name": "E3 ubiquitin-protein ligase SH3RF2, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035795",
"name": "E3 ubiquitin-protein ligase SH3RF1, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035797",
"name": "ARHGEF16/ARHGEF26, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035800",
"name": "Sla1, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035816",
"name": "SH3RF1/SH3RF3, fourth SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035817",
"name": "Dynamin-binding protein, first N-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035818",
"name": "Dynamin-binding protein, second N-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035819",
"name": "Dynamin-binding protein, third N-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035820",
"name": "Dynamin-binding protein, first C-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035821",
"name": "Sla1, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035822",
"name": "SH3RF2, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035823",
"name": "ARHGEF37, first C-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035824",
"name": "Endophilin-A, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035825",
"name": "Alpha Spectrin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035832",
"name": "Jouberin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035833",
"name": "SGSM3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035834",
"name": "SH3 domain-containing protein 19, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035835",
"name": "SH3 domain-containing protein 19, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035836",
"name": "ASAP1-like, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR038016",
"name": "ASAP1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041615",
"name": "Desmoplakin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042722",
"name": "RelA-associated inhibitor, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047015",
"name": "VAV3 protein, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047025",
"name": "Dedicator of cytokinesis protein 1/5, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047053",
"name": "Kalirin/Triple functional domain protein, SH3 domain 2",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "SH3 domain-containing kinase-binding protein 1, first SH3 domain",
"short": "CIN85_SH3_1"
},
"description": [
{
"text": "<p>CIN85, also called SH3 domain-containing kinase-binding protein 1 (SH3KBP1), CD2-binding protein 3 (CD2BP3) or Ruk, is an adaptor protein that is involved in the downregulation of receptor tyrosine kinases by facilitating endocytosis through interaction with endophilin-associated ubiquitin ligase Cbl proteins [[cite:PUB00086155], [cite:PUB00086156], [cite:PUB00086157]]. It is also important in many other cellular processes including vesicle-mediated transport, cytoskeletal remodelling, apoptosis, cell adhesion and migration, and viral infection, among others [[cite:PUB00086158]]. CIN85 exists as multiple variants from alternative splicing; the main variant contains three SH3 domains, a proline-rich region, and a C-terminal coiled-coil domain. All of these domains enable CIN85 to bind various protein partners and assemble complexes that have been implicated in many different functions.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This entry represents the first SH3 domain (SH3A) of CIN85; SH3A binds to internal proline-rich motifs within the proline-rich region. This intramolecular interaction serves as a regulatory mechanism to keep CIN85 in a closed conformation, preventing the recruitment of other proteins. SH3A has also been shown to bind ubiquitin and to an atypical PXXXPR motif at the C terminus of Cbl and the cytoplasmic end of the cell adhesion protein CD2 [[cite:PUB00086159]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00086155": {
"PMID": 22262777,
"ISBN": null,
"volume": "119",
"issue": "10",
"year": 2012,
"title": "CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells.",
"URL": null,
"raw_pages": "2263-73",
"medline_journal": "Blood",
"ISO_journal": "Blood",
"authors": [
"Niiro H",
"Jabbarzadeh-Tabrizi S",
"Kikushige Y",
"Shima T",
"Noda K",
"Ota S",
"Tsuzuki H",
"Inoue Y",
"Arinobu Y",
"Iwasaki H",
"Shimoda S",
"Baba E",
"Tsukamoto H",
"Horiuchi T",
"Taniyama T",
"Akashi K."
],
"DOI_URL": "https://doi.org/10.1182/blood-2011-04-351965"
},
"PUB00086156": {
"PMID": 12177062,
"ISBN": null,
"volume": "277",
"issue": "42",
"year": 2002,
"title": "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.",
"URL": null,
"raw_pages": "39666-72",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Szymkiewicz I",
"Kowanetz K",
"Soubeyran P",
"Dinarina A",
"Lipkowitz S",
"Dikic I."
],
"DOI_URL": "https://doi.org/10.1074/jbc.M205535200"
},
"PUB00086157": {
"PMID": 12354621,
"ISBN": null,
"volume": "529",
"issue": "1",
"year": 2002,
"title": "CIN85/CMS family of adaptor molecules.",
"URL": null,
"raw_pages": "110-5",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett.",
"authors": [
"Dikic I."
],
"DOI_URL": "https://doi.org/10.1016/S0014-5793(02)03188-5"
},
"PUB00086158": {
"PMID": 20331533,
"ISBN": null,
"volume": "11",
"issue": "6",
"year": 2010,
"title": "Emerging roles of Ruk/CIN85 in vesicle-mediated transport, adhesion, migration and malignancy.",
"URL": null,
"raw_pages": "721-31",
"medline_journal": "Traffic",
"ISO_journal": "Traffic",
"authors": [
"Havrylov S",
"Redowicz MJ",
"Buchman VL."
],
"DOI_URL": "https://doi.org/10.1111/j.1600-0854.2010.01061.x"
},
"PUB00086159": {
"PMID": 18769463,
"ISBN": null,
"volume": "15",
"issue": "9",
"year": 2008,
"title": "Reply to \"The binding stoichiometry of CIN85 SH3 domain A and Cbl-b\".",
"URL": null,
"raw_pages": "891-2",
"medline_journal": "Nat Struct Mol Biol",
"ISO_journal": "Nat. Struct. Mol. Biol.",
"authors": [
"Jozic D",
"Cardenes N",
"Deribe YL",
"Moncalian G",
"Hoeller D",
"Groemping Y",
"Dikic I",
"Rittinger K",
"Bravo J."
],
"DOI_URL": "https://doi.org/10.1038/nsmb0908-891"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036028",
"name": "SH3-like domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 958,
"pathways": 20,
"proteins": 958,
"proteomes": 456,
"sets": 0,
"structural_models": {
"alphafold": 875,
"bfvd": 0
},
"structures": 0,
"taxa": 1505
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
