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{
"metadata": {
"accession": "IPR034967",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0004535",
"name": "poly(A)-specific ribonuclease activity",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd10312": "C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR005135",
"name": "Endonuclease/exonuclease/phosphatase",
"type": "Domain",
"children": [
{
"accession": "IPR000300",
"name": "Inositol polyphosphate-related phosphatase",
"type": "Domain",
"children": [
{
"accession": "IPR037793",
"name": "OCRL1/INPP5B, INPP5c domain",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR034965",
"name": "Nocturnin, deadenylase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034966",
"name": "CCR4-NOT transcription complex subunit 6",
"type": "Domain",
"children": []
},
{
"accession": "IPR034967",
"name": "CCR4-NOT transcription complex subunit 6-like",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "CCR4-NOT transcription complex subunit 6-like",
"short": "Deadenylase_CCR4b"
},
"description": [
{
"text": "<p>This entry represents the C-terminal catalytic domain of the deadenylase CCR4b, also known as CCR4-NOT transcription complex subunit 6-like (CNOT6L). CCR4 belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. In S. cerevisiae, CCR4 is the major deadenylase subunit of the CCR4-NOT transcription complex, which contains two deadenylase subunits and several noncatalytic subunits [[cite:PUB00019239], [cite:PUB00084731]].</p>\r\n\r\n<p>There are two vertebrate CCR4 proteins, CCR4a (also called CCR4-NOT transcription complex subunit 6 or CNOT6) and CCR4b. CCR4b associates with other components, such as CNOT1-3 and Caf1, to form a CCR4-NOT multisubunit complex, which regulates transcription and mRNA degradation [[cite:PUB00084732]]. The nuclease domain of CCR4b exhibits Mg2+-dependent deadenylase activity with strict specificity for poly (A) RNA as substrate [[cite:PUB00084724]]. CCR4b is mainly localized in the cytoplasm. It regulates cell growth and influences cell cycle progression by regulating p27/Kip1 mRNA levels [[cite:PUB00084733]]. It contributes to the prevention of cell death by regulating insulin-like growth factor-binding protein 5 [[cite:PUB00084722]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00019239": {
"PMID": 11239395,
"ISBN": null,
"volume": "104",
"issue": "3",
"year": 2001,
"title": "The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae.",
"URL": null,
"raw_pages": "377-86",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Tucker M",
"Valencia-Sanchez MA",
"Staples RR",
"Chen J",
"Denis CL",
"Parker R."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0092-8674(01)00225-2"
},
"PUB00084722": {
"PMID": 21233283,
"ISBN": null,
"volume": "22",
"issue": "6",
"year": 2011,
"title": "The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence.",
"URL": null,
"raw_pages": "748-58",
"medline_journal": "Mol Biol Cell",
"ISO_journal": "Mol. Biol. Cell",
"authors": [
"Mittal S",
"Aslam A",
"Doidge R",
"Medica R",
"Winkler GS."
],
"DOI_URL": "https://doi.org/10.1091/mbc.E10-11-0898"
},
"PUB00084724": {
"PMID": 20628353,
"ISBN": null,
"volume": "29",
"issue": "15",
"year": 2010,
"title": "Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.",
"URL": null,
"raw_pages": "2566-76",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Wang H",
"Morita M",
"Yang X",
"Suzuki T",
"Yang W",
"Wang J",
"Ito K",
"Wang Q",
"Zhao C",
"Bartlam M",
"Yamamoto T",
"Rao Z."
],
"DOI_URL": "https://doi.org/10.1038/emboj.2010.152"
},
"PUB00084733": {
"PMID": 17452450,
"ISBN": null,
"volume": "27",
"issue": "13",
"year": 2007,
"title": "Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.",
"URL": null,
"raw_pages": "4980-90",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Morita M",
"Suzuki T",
"Nakamura T",
"Yokoyama K",
"Miyasaka T",
"Yamamoto T."
],
"DOI_URL": "https://doi.org/10.1128/MCB.02304-06"
},
"PUB00084731": {
"PMID": 11889048,
"ISBN": null,
"volume": "21",
"issue": "6",
"year": 2002,
"title": "Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae.",
"URL": null,
"raw_pages": "1427-36",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Tucker M",
"Staples RR",
"Valencia-Sanchez MA",
"Muhlrad D",
"Parker R."
],
"DOI_URL": "https://doi.org/10.1093/emboj/21.6.1427"
},
"PUB00084732": {
"PMID": 22817755,
"ISBN": null,
"volume": "40",
"issue": "4",
"year": 2012,
"title": "Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex.",
"URL": null,
"raw_pages": "896-901",
"medline_journal": "Biochem Soc Trans",
"ISO_journal": "Biochem. Soc. Trans.",
"authors": [
"Doidge R",
"Mittal S",
"Aslam A",
"Winkler GS."
],
"DOI_URL": "https://doi.org/10.1042/BST20120074"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036691",
"name": "Endonuclease/exonuclease/phosphatase superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 753,
"pathways": 5,
"proteins": 753,
"proteomes": 525,
"sets": 0,
"structural_models": {
"alphafold": 700,
"bfvd": 0
},
"structures": 6,
"taxa": 1610
},
"entry_annotations": {},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "3.1.13.4",
"url": "https://enzyme.expasy.org/EC/3.1.13.4"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "3ngq",
"name": "Crystal structure of the human CNOT6L nuclease domain"
}
}
}
