HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "IPR034270",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0005515",
"name": "protein binding",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd10482": "Ligand Binding Domain of Ephrin type-A Receptor 4"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001090",
"name": "Ephrin, ligand binding domain",
"type": "Domain",
"children": [
{
"accession": "IPR034231",
"name": "Ephrin type-B receptor 1, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034238",
"name": "Ephrin type-B receptor 2, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034245",
"name": "Ephrin type-B receptor 3, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034251",
"name": "Ephrin type-A receptor 1, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034263",
"name": "Ephrin type-A receptor 2, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034266",
"name": "Ephrin type-A receptor 3, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034270",
"name": "Ephrin type-A receptor 4, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034277",
"name": "Ephrin type-A receptor 5, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034280",
"name": "Ephrin type-A receptor 6, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034283",
"name": "Ephrin type-A receptor 7, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034287",
"name": "Ephrin type-A receptor 8, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034290",
"name": "Ephrin type-B receptor 4, ligand binding domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Ephrin type-A receptor 4, ligand binding domain",
"short": "EphA4_rcpt_lig-bd"
},
"description": [
{
"text": "<p>This entry represents the ligand-binding domain found in ephrin type-A receptor 4 (EphA4). A loss of EphA4, as well as EphB2, precedes memory decline in a murine model of Alzheimers disease [[cite:PUB00082948]]. EphA4 has been shown to have a negative effect on axon regeneration and functional restoration in corticospinal lesions and has been implicated in circadian sleep regulation [[cite:PUB00083060], [cite:PUB00083061]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands [[cite:PUB00082927], [cite:PUB00082933]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) [[cite:PUB00082927]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00083060": {
"PMID": 16939977,
"ISBN": null,
"volume": "361",
"issue": "1473",
"year": 2006,
"title": "Extracellular regulators of axonal growth in the adult central nervous system.",
"URL": null,
"raw_pages": "1593-610",
"medline_journal": "Philos Trans R Soc Lond B Biol Sci",
"ISO_journal": "Philos. Trans. R. Soc. Lond., B, Biol. Sci.",
"authors": [
"Liu BP",
"Cafferty WB",
"Budel SO",
"Strittmatter SM."
],
"DOI_URL": "http://dx.doi.org/10.1098/rstb.2006.1891"
},
"PUB00083061": {
"PMID": 26612390,
"ISBN": null,
"volume": "39",
"issue": "3",
"year": 2016,
"title": "EphA4 is Involved in Sleep Regulation but Not in the Electrophysiological Response to Sleep Deprivation.",
"URL": null,
"raw_pages": "613-24",
"medline_journal": "Sleep",
"ISO_journal": "Sleep",
"authors": [
"Freyburger M",
"Pierre A",
"Paquette G",
"Belanger-Nelson E",
"Bedont J",
"Gaudreault PO",
"Drolet G",
"Laforest S",
"Blackshaw S",
"Cermakian N",
"Doucet G",
"Mongrain V."
],
"DOI_URL": "http://dx.doi.org/10.5665/sleep.5538"
},
"PUB00082933": {
"PMID": 18413883,
"ISBN": null,
"volume": "1",
"issue": "15",
"year": 2008,
"title": "Eph, a protein family coming of age: more confusion, insight, or complexity?",
"URL": null,
"raw_pages": "re2",
"medline_journal": "Sci Signal",
"ISO_journal": "Sci Signal",
"authors": [
"Lackmann M",
"Boyd AW."
],
"DOI_URL": "http://dx.doi.org/10.1126/stke.115re2"
},
"PUB00082948": {
"PMID": 19542617,
"ISBN": null,
"volume": "17",
"issue": "4",
"year": 2009,
"title": "Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease.",
"URL": null,
"raw_pages": "773-86",
"medline_journal": "J Alzheimers Dis",
"ISO_journal": "J. Alzheimers Dis.",
"authors": [
"Simon AM",
"de Maturana RL",
"Ricobaraza A",
"Escribano L",
"Schiapparelli L",
"Cuadrado-Tejedor M",
"Perez-Mediavilla A",
"Avila J",
"Del Rio J",
"Frechilla D."
],
"DOI_URL": "http://dx.doi.org/10.3233/JAD-2009-1096"
},
"PUB00082927": {
"PMID": 12495863,
"ISBN": null,
"volume": "26",
"issue": "1",
"year": 2003,
"title": "Eph signaling: a structural view.",
"URL": null,
"raw_pages": "46-51",
"medline_journal": "Trends Neurosci",
"ISO_journal": "Trends Neurosci.",
"authors": [
"Himanen JP",
"Nikolov DB."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0166-2236(02)00005-X"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR008979",
"name": "Galactose-binding-like domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 911,
"pathways": 10,
"proteins": 911,
"proteomes": 498,
"sets": 0,
"structural_models": {
"alphafold": 844,
"bfvd": 0
},
"structures": 17,
"taxa": 1671
},
"entry_annotations": {},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "2.7.10.1",
"url": "https://enzyme.expasy.org/EC/2.7.10.1"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "5jr2",
"name": "Crystal structure of the EphA4 LBD in complex with APYd3 peptide inhibitor"
}
}
}
