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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR034231",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0005515",
"name": "protein binding",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd10476": "Ligand Binding Domain of Ephrin type-B Receptor 1"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001090",
"name": "Ephrin, ligand binding domain",
"type": "Domain",
"children": [
{
"accession": "IPR034231",
"name": "Ephrin type-B receptor 1, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034238",
"name": "Ephrin type-B receptor 2, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034245",
"name": "Ephrin type-B receptor 3, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034251",
"name": "Ephrin type-A receptor 1, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034263",
"name": "Ephrin type-A receptor 2, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034266",
"name": "Ephrin type-A receptor 3, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034270",
"name": "Ephrin type-A receptor 4, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034277",
"name": "Ephrin type-A receptor 5, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034280",
"name": "Ephrin type-A receptor 6, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034283",
"name": "Ephrin type-A receptor 7, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034287",
"name": "Ephrin type-A receptor 8, ligand binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034290",
"name": "Ephrin type-B receptor 4, ligand binding domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Ephrin type-B receptor 1, ligand binding domain",
"short": "EphB1_rcpt_lig-bd"
},
"description": [
{
"text": "<p>This entry represents the ligand-binding domain found in ephrin type-B receptor 1 (EphB1). Using EphB1 knockout-mice, EphB1 has been shown to be essential to the development of long-term potentiation (LTP) [[cite:PUB00082928]], a cellular model of synaptic plasticity, learning and memory formation [[cite:PUB00082926], [cite:PUB00082929], [cite:PUB00082930]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Class EphB receptors bind to transmembrane ephrin-B ligands. There are six vertebrate EhpB receptors (EphB1-6), which display promiscuous interactions with three ephrin-B ligands [[cite:PUB00082927]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) [[cite:PUB00082927]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00082930": {
"PMID": 18424888,
"ISBN": null,
"volume": "73",
"issue": "3-4",
"year": 2007,
"title": "Loss of expression of EphB1 protein in gastric carcinoma associated with invasion and metastasis.",
"URL": null,
"raw_pages": "238-45",
"medline_journal": "Oncology",
"ISO_journal": "Oncology",
"authors": [
"Wang JD",
"Dong YC",
"Sheng Z",
"Ma HH",
"Li GL",
"Wang XL",
"Lu GM",
"Sugimura H",
"Jin J",
"Zhou XJ."
],
"DOI_URL": "http://dx.doi.org/10.1159/000127421"
},
"PUB00082929": {
"PMID": 12971893,
"ISBN": null,
"volume": "39",
"issue": "6",
"year": 2003,
"title": "Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm.",
"URL": null,
"raw_pages": "919-35",
"medline_journal": "Neuron",
"ISO_journal": "Neuron",
"authors": [
"Williams SE",
"Mann F",
"Erskine L",
"Sakurai T",
"Wei S",
"Rossi DJ",
"Gale NW",
"Holt CE",
"Mason CA",
"Henkemeyer M."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.neuron.2003.08.017"
},
"PUB00082928": {
"PMID": 19523204,
"ISBN": null,
"volume": "5",
"issue": null,
"year": 2009,
"title": "An in vivo mouse model of long-term potentiation at synapses between primary afferent C-fibers and spinal dorsal horn neurons: essential role of EphB1 receptor.",
"URL": null,
"raw_pages": "29",
"medline_journal": "Mol Pain",
"ISO_journal": "Mol Pain",
"authors": [
"Liu WT",
"Han Y",
"Li HC",
"Adams B",
"Zheng JH",
"Wu YP",
"Henkemeyer M",
"Song XJ."
],
"DOI_URL": "http://dx.doi.org/10.1186/1744-8069-5-29"
},
"PUB00082927": {
"PMID": 12495863,
"ISBN": null,
"volume": "26",
"issue": "1",
"year": 2003,
"title": "Eph signaling: a structural view.",
"URL": null,
"raw_pages": "46-51",
"medline_journal": "Trends Neurosci",
"ISO_journal": "Trends Neurosci.",
"authors": [
"Himanen JP",
"Nikolov DB."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0166-2236(02)00005-X"
},
"PUB00082926": {
"PMID": 21514363,
"ISBN": null,
"volume": "496",
"issue": "3",
"year": 2011,
"title": "Involvement of EphB1 receptor/ephrinB1 ligand in bone cancer pain.",
"URL": null,
"raw_pages": "163-7",
"medline_journal": "Neurosci Lett",
"ISO_journal": "Neurosci. Lett.",
"authors": [
"Dong Y",
"Mao-Ying QL",
"Chen JW",
"Yang CJ",
"Wang YQ",
"Tan ZM."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.neulet.2011.04.008"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR008979",
"name": "Galactose-binding-like domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 496,
"pathways": 12,
"proteins": 496,
"proteomes": 282,
"sets": 0,
"structural_models": {
"alphafold": 447,
"bfvd": 0
},
"structures": 0,
"taxa": 952
},
"entry_annotations": {},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "2.7.10.1",
"url": "https://enzyme.expasy.org/EC/2.7.10.1"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
