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{
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{
"identifier": "GO:0000381",
"name": "regulation of alternative mRNA splicing, via spliceosome",
"category": {
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"name": "biological_process"
}
},
{
"identifier": "GO:0016556",
"name": "mRNA modification",
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"name": "biological_process"
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{
"identifier": "GO:0005634",
"name": "nucleus",
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"pfam": {
"PF17098": "WTAP/Mum2p family"
},
"panther": {
"PTHR15217": "WILMS' TUMOR 1-ASSOCIATING PROTEIN"
}
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"accession": "IPR033757",
"name": "Pre-mRNA-splicing regulator WTAP",
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"name": {
"name": "Pre-mRNA-splicing regulator WTAP",
"short": "WTAP"
},
"description": [
{
"text": "<p>Pre-mRNA-splicing regulator WTAP (Wilms' tumor 1-associating protein) is a regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) formation, which acts as an epitranscriptomic marker [[cite:PUB00070686], [cite:PUB00070693]]. It plays a role in the efficiency of mRNA splicing and processing, and mRNA stability [[cite:PUB00070694]]. In Drosophila, the homologous protein pfemale-lethal(2)D has been implicated in alternative splicing regulation of genes involved in sexual determination [[cite:PUB00070687]] and is required for eye development [[cite:PUB00070692]]. FKBP12-interacting protein of 37kDa (AtFIP37, At3g54170), the homologue from Arabidopsis, may also have a role in splicing events [[cite:PUB00070703]]. AtFIP37 interacts with mRNA adenosine methylase (MTA, encoded by At4g10760) in vitro and in vivo [[cite:PUB00070913]].</p>",
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"PMID": 15047892,
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"volume": "134",
"issue": "4",
"year": 2004,
"title": "The immunophilin-interacting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication.",
"URL": null,
"raw_pages": "1283-92",
"medline_journal": "Plant Physiol",
"ISO_journal": "Plant Physiol.",
"authors": [
"Vespa L",
"Vachon G",
"Berger F",
"Perazza D",
"Faure JD",
"Herzog M."
],
"DOI_URL": "http://dx.doi.org/10.1104/pp.103.028050"
},
"PUB00070686": {
"PMID": 24407421,
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"volume": "24",
"issue": "2",
"year": 2014,
"title": "Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.",
"URL": null,
"raw_pages": "177-89",
"medline_journal": "Cell Res",
"ISO_journal": "Cell Res.",
"authors": [
"Ping XL",
"Sun BF",
"Wang L",
"Xiao W",
"Yang X",
"Wang WJ",
"Adhikari S",
"Shi Y",
"Lv Y",
"Chen YS",
"Zhao X",
"Li A",
"Yang Y",
"Dahal U",
"Lou XM",
"Liu X",
"Huang J",
"Yuan WP",
"Zhu XF",
"Cheng T",
"Zhao YL",
"Wang X",
"Rendtlew Danielsen JM",
"Liu F",
"Yang YG."
],
"DOI_URL": "http://dx.doi.org/10.1038/cr.2014.3"
},
"PUB00070687": {
"PMID": 12444081,
"ISBN": null,
"volume": "278",
"issue": "5",
"year": 2003,
"title": "Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing.",
"URL": null,
"raw_pages": "3040-7",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Ortega A",
"Niksic M",
"Bachi A",
"Wilm M",
"Sanchez L",
"Hastie N",
"Valcarcel J."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M210737200"
},
"PUB00070694": {
"PMID": 17088532,
"ISBN": null,
"volume": "103",
"issue": "46",
"year": 2006,
"title": "Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA.",
"URL": null,
"raw_pages": "17278-83",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Horiuchi K",
"Umetani M",
"Minami T",
"Okayama H",
"Takada S",
"Yamamoto M",
"Aburatani H",
"Reid PC",
"Housman DE",
"Hamakubo T",
"Kodama T."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.0608357103"
},
"PUB00070913": {
"PMID": 18505803,
"ISBN": null,
"volume": "20",
"issue": "5",
"year": 2008,
"title": "MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor.",
"URL": null,
"raw_pages": "1278-88",
"medline_journal": "Plant Cell",
"ISO_journal": "Plant Cell",
"authors": [
"Zhong S",
"Li H",
"Bodi Z",
"Button J",
"Vespa L",
"Herzog M",
"Fray RG."
],
"DOI_URL": "http://dx.doi.org/10.1105/tpc.108.058883"
},
"PUB00070693": {
"PMID": 24316715,
"ISBN": null,
"volume": "10",
"issue": "2",
"year": 2014,
"title": "A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.",
"URL": null,
"raw_pages": "93-5",
"medline_journal": "Nat Chem Biol",
"ISO_journal": "Nat. Chem. Biol.",
"authors": [
"Liu J",
"Yue Y",
"Han D",
"Wang X",
"Fu Y",
"Zhang L",
"Jia G",
"Yu M",
"Lu Z",
"Deng X",
"Dai Q",
"Chen W",
"He C."
],
"DOI_URL": "http://dx.doi.org/10.1038/nchembio.1432"
},
"PUB00070692": {
"PMID": 24690230,
"ISBN": null,
"volume": "390",
"issue": "2",
"year": 2014,
"title": "The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development.",
"URL": null,
"raw_pages": "170-80",
"medline_journal": "Dev Biol",
"ISO_journal": "Dev. Biol.",
"authors": [
"Anderson AM",
"Weasner BP",
"Weasner BM",
"Kumar JP."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.ydbio.2014.03.012"
}
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