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{
    "metadata": {
        "accession": "IPR032355",
        "entry_id": null,
        "type": "domain",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "profile": {
                "PS51983": "CUT repeat-like (CUTL) domain profile"
            },
            "pfam": {
                "PF16557": "CUT1-like DNA-binding domain of SATB"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR032355",
            "name": "SATB, CUT1-like DNA-binding domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "SATB, CUT1-like DNA-binding domain",
            "short": "CUTL"
        },
        "description": [
            {
                "text": "<p>The CUTL domain is part of the N-terminal region of SATB proteins, special AT-rich sequence-binding proteins that are global chromatin organisers and gene expression regulators essential for T-cell development and breast cancer tumour growth and metastasis. This domain carries a DNA-binding region [[cite:PUB00076270], [cite:PUB00097436]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00076270": {
                "PMID": 22241778,
                "ISBN": null,
                "volume": "40",
                "issue": "9",
                "year": 2012,
                "title": "The structural basis for the oligomerization of the N-terminal domain of SATB1.",
                "URL": null,
                "raw_pages": "4193-202",
                "medline_journal": "Nucleic Acids Res",
                "ISO_journal": "Nucleic Acids Res.",
                "authors": [
                    "Wang Z",
                    "Yang X",
                    "Chu X",
                    "Zhang J",
                    "Zhou H",
                    "Shen Y",
                    "Long J."
                ],
                "DOI_URL": "http://dx.doi.org/10.1093/nar/gkr1284"
            },
            "PUB00097436": {
                "PMID": 25124042,
                "ISBN": null,
                "volume": "289",
                "issue": "40",
                "year": 2014,
                "title": "Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism.",
                "URL": null,
                "raw_pages": "27376-85",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J Biol Chem",
                "authors": [
                    "Wang Z",
                    "Yang X",
                    "Guo S",
                    "Yang Y",
                    "Su XC",
                    "Shen Y",
                    "Long J."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR038216",
                "name": "SATB, CUTL domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 34,
            "interactions": 0,
            "matches": 2910,
            "pathways": 5,
            "proteins": 2909,
            "proteomes": 769,
            "sets": 0,
            "structural_models": {
                "alphafold": 2623,
                "bfvd": 0
            },
            "structures": 3,
            "taxa": 2468
        },
        "entry_annotations": {
            "alignment:seed": 3,
            "alignment:full": 2152
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "3nzl",
            "name": "Crystal Structure of the N-terminal domain of DNA-binding protein SATB1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4435B"
        }
    }
}