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{
"metadata": {
"accession": "IPR031967",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF16736": "Single Cache-like"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR031967",
"name": "PhoR, single Cache-like domain",
"type": "Domain",
"children": []
},
"name": {
"name": "PhoR, single Cache-like domain",
"short": "PhoR_single_Cache-like_dom"
},
"description": [
{
"text": "<p>This entry represents the N-terminal Cache-like domain of the alkaline phosphatase synthesis sensor protein PhoR. It covers part of the PAS-like fold that share a central five-stranded β-sheet of identical topology to other PAS domains [[cite:PUB00057686]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2 channel alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00017181": {
"PMID": 11084361,
"ISBN": null,
"volume": "25",
"issue": "11",
"year": 2000,
"title": "Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors.",
"URL": null,
"raw_pages": "535-7",
"medline_journal": "Trends Biochem Sci",
"ISO_journal": "Trends Biochem. Sci.",
"authors": [
"Anantharaman V",
"Aravind L."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0968-0004(00)01672-8"
},
"PUB00007364": {
"PMID": 11292341,
"ISBN": null,
"volume": "307",
"issue": "5",
"year": 2001,
"title": "Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains.",
"URL": null,
"raw_pages": "1271-92",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Anantharaman V",
"Koonin EV",
"Aravind L."
],
"DOI_URL": "http://dx.doi.org/10.1006/jmbi.2001.4508"
},
"PUB00057686": {
"PMID": 20008068,
"ISBN": null,
"volume": "192",
"issue": "4",
"year": 2010,
"title": "Extracytoplasmic PAS-like domains are common in signal transduction proteins.",
"URL": null,
"raw_pages": "1156-9",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Chang C",
"Tesar C",
"Gu M",
"Babnigg G",
"Joachimiak A",
"Pokkuluri PR",
"Szurmant H",
"Schiffer M."
],
"DOI_URL": "http://dx.doi.org/10.1128/JB.01508-09"
},
"PUB00078916": {
"PMID": 27049771,
"ISBN": null,
"volume": "12",
"issue": "4",
"year": 2016,
"title": "Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes.",
"URL": null,
"raw_pages": "e1004862",
"medline_journal": "PLoS Comput Biol",
"ISO_journal": "PLoS Comput. Biol.",
"authors": [
"Upadhyay AA",
"Fleetwood AD",
"Adebali O",
"Finn RD",
"Zhulin IB."
],
"DOI_URL": "http://dx.doi.org/10.1371/journal.pcbi.1004862"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 24,
"interactions": 0,
"matches": 1673,
"pathways": 0,
"proteins": 1673,
"proteomes": 987,
"sets": 0,
"structural_models": {
"alphafold": 1336,
"bfvd": 0
},
"structures": 1,
"taxa": 1876
},
"entry_annotations": {
"alignment:seed": 5,
"alignment:full": 571
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
