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{
    "metadata": {
        "accession": "IPR031892",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF15968": "Membrane-anchored ion channel, Abi component"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR031892",
            "name": "Abi component, membrane-anchored ion channel RexB",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Abi component, membrane-anchored ion channel RexB",
            "short": "RexB"
        },
        "description": [
            {
                "text": "<p>RexB is a family of anti-lambda phage inner-membrane ion-channels with four transmembrane domains [[cite:PUB00076113]]. On infection by phage, a phage protein-DNA complex is produced as a replication or recombination intermediate which activates RexA. RexA is an intracellular sensor that activates the membrane-anchored RexB. At least two RexA proteins are needed to activate one RexB protein. Activation opens the ion-channel leading to a drop in membrane potential, the outcome of which is the death of the host cell but also the cessation or abortion of the phage infection. RexA-RexB is one of the most well characterised bacterial abortive infection systems, or Abis [[cite:PUB00056243]].</p>",
                "llm": false,
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            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00076113": {
                "PMID": 9860994,
                "ISBN": null,
                "volume": "95",
                "issue": "26",
                "year": 1998,
                "title": "rexB of bacteriophage lambda is an anti-cell death gene.",
                "URL": null,
                "raw_pages": "15481-6",
                "medline_journal": "Proc Natl Acad Sci U S A",
                "ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
                "authors": [
                    "Engelberg-Kulka H",
                    "Reches M",
                    "Narasimhan S",
                    "Schoulaker-Schwarz R",
                    "Klemes Y",
                    "Aizenman E",
                    "Glaser G."
                ],
                "DOI_URL": "http://dx.doi.org/10.1073/pnas.95.26.15481"
            },
            "PUB00056243": {
                "PMID": 20348932,
                "ISBN": null,
                "volume": "8",
                "issue": "5",
                "year": 2010,
                "title": "Bacteriophage resistance mechanisms.",
                "URL": null,
                "raw_pages": "317-27",
                "medline_journal": "Nat Rev Microbiol",
                "ISO_journal": "Nat. Rev. Microbiol.",
                "authors": [
                    "Labrie SJ",
                    "Samson JE",
                    "Moineau S."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/nrmicro2315"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 2,
            "interactions": 0,
            "matches": 64,
            "pathways": 0,
            "proteins": 64,
            "proteomes": 21,
            "sets": 0,
            "structural_models": {
                "alphafold": 54,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 184
        },
        "entry_annotations": {
            "alignment:seed": 1,
            "alignment:full": 8
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}