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{
"metadata": {
"accession": "IPR031161",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"smart": {
"SM01276": "Peptidase M60-like family"
},
"profile": {
"PS51723": "Peptidase family M60 domain profile"
},
"pfam": {
"PF13402": "Peptidase M60, enhancin and enhancin-like"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR031161",
"name": "Peptidase family M60 domain",
"type": "Domain",
"children": []
},
"name": {
"name": "Peptidase family M60 domain",
"short": "Peptidase_M60_dom"
},
"description": [
{
"text": "<p>The peptidase family M60 domain belongs to the Merops zincin superfamily of zinc-requiring metalloproteases (clan MA, subclan MA(E)). The peptidase family M60 domain contains the metal-binding consensus motif HExxH. The two histidine residues are ligands of the catalytic Zn(2) and the glutamic acid residue is involved in nucleophilic attack. An additional conserved glutamic acid is found approximately 20 residues from the first histidine within the metal-binding motif. The second conserved glutamic acid potentially acts as a third proteous Zn(2) ligand. The peptidase family M60 domain targets complex host glycoproteins, such as mucins [[cite:PUB00074817], [cite:PUB00074818], [cite:PUB00074819], [cite:PUB00074820], [cite:PUB00074821]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Some proteins known to contain a peptidase family M60 domain are listed below:</p>\n\n<ul><li>Baculovirus viral enhancing factor (VEF), also known as Enhancin, a metalloprotease that enhances viral infection by degrading the peritrophic membrane (PM) of the insect midgut.</li>\n\n<li>Bacteria enhancin-like metalloproteases.</li>\n\n<li>Mammalian FAM115 family proteins (also known as TRPM8 channel-associated factor 1-3).</li></ul>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00074817": {
"PMID": 9343163,
"ISBN": null,
"volume": "71",
"issue": "11",
"year": 1997,
"title": "Molecular analysis of an enhancin gene in the Lymantria dispar nuclear polyhedrosis virus.",
"URL": null,
"raw_pages": "8133-40",
"medline_journal": "J Virol",
"ISO_journal": "J. Virol.",
"authors": [
"Bischoff DS",
"Slavicek JM."
],
"DOI_URL": null
},
"PUB00074818": {
"PMID": 16081094,
"ISBN": null,
"volume": "90",
"issue": "2",
"year": 2005,
"title": "Comparison of the bacterial Enhancin-like proteins from Yersinia and Bacillus spp. with a baculovirus Enhancin.",
"URL": null,
"raw_pages": "134-7",
"medline_journal": "J Invertebr Pathol",
"ISO_journal": "J. Invertebr. Pathol.",
"authors": [
"Galloway CS",
"Wang P",
"Winstanley D",
"Jones IM."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.jip.2005.06.008"
},
"PUB00074819": {
"PMID": 16790012,
"ISBN": null,
"volume": "260",
"issue": "1",
"year": 2006,
"title": "The enhancin-like metalloprotease from the Bacillus cereus group is regulated by the pleiotropic transcriptional activator PlcR but is not essential for larvicidal activity.",
"URL": null,
"raw_pages": "9-16",
"medline_journal": "FEMS Microbiol Lett",
"ISO_journal": "FEMS Microbiol. Lett.",
"authors": [
"Hajaij-Ellouze M",
"Fedhila S",
"Lereclus D",
"Nielsen-LeRoux C."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1574-6968.2006.00289.x"
},
"PUB00074820": {
"PMID": 22238230,
"ISBN": null,
"volume": "93",
"issue": "Pt 4",
"year": 2012,
"title": "Role of enhancin in Mamestra configurata nucleopolyhedrovirus virulence: selective degradation of host peritrophic matrix proteins.",
"URL": null,
"raw_pages": "744-53",
"medline_journal": "J Gen Virol",
"ISO_journal": "J. Gen. Virol.",
"authors": [
"Toprak U",
"Harris S",
"Baldwin D",
"Theilmann D",
"Gillott C",
"Hegedus DD",
"Erlandson MA."
],
"DOI_URL": "http://dx.doi.org/10.1099/vir.0.038117-0"
},
"PUB00074821": {
"PMID": 22299034,
"ISBN": null,
"volume": "7",
"issue": "1",
"year": 2012,
"title": "A novel extracellular metallopeptidase domain shared by animal host-associated mutualistic and pathogenic microbes.",
"URL": null,
"raw_pages": "e30287",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS ONE",
"authors": [
"Nakjang S",
"Ndeh DA",
"Wipat A",
"Bolam DN",
"Hirt RP."
],
"DOI_URL": "http://dx.doi.org/10.1371/journal.pone.0030287"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR042279",
"name": "Peptidase M60, enhancin-like domain 3",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 345,
"interactions": 0,
"matches": 6517,
"pathways": 0,
"proteins": 6503,
"proteomes": 1929,
"sets": 0,
"structural_models": {
"alphafold": 4774,
"bfvd": 9
},
"structures": 20,
"taxa": 5155
},
"entry_annotations": {
"alignment:seed": 20,
"alignment:full": 2322
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "7yx8",
"name": "Crystal structure of the AM0627 (E326A) inactive mutant in complex with PSGL-1-like bis-T glycopeptide and Zn2+"
}
}
}
