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{
"metadata": {
"accession": "IPR030217",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"panther": {
"PTHR10662": "NUCLEAR RNA EXPORT FACTOR"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR030217",
"name": "Nuclear RNA export factor",
"type": "Family",
"children": []
},
"name": {
"name": "Nuclear RNA export factor",
"short": "NXF_fam"
},
"description": [
{
"text": "<p>Mex67 is involved in the export of mRNA from the nucleus to the cytoplasm in Saccharomyces cerevisiae [[cite:PUB00071961]]. Vertebrate TAP (also called NXF1 for nuclear RNA export factor 1) is the orthologue of Mex67 [[cite:PUB00071960]]. TAP belongs to a multigene family with conserved modular architecture [[cite:PUB00018170]]. Other members of the family in humans are NXF2, NXF3, and NFX5. Both TAP(NXF1) and NXF2 bind mRNA and display RNA nuclear export activity [[cite:PUB00071970]]. NXF3 also has the ability to export mRNA from the nucleus to the cytoplasm but it uses a different mechanism [[cite:PUB00071958]]. NXF1 and NXF2 are predominantly nuclear, whereas the cytoplasmic presence of NXF3 and NXF5 suggests that they have a different cellular function [[cite:PUB00018170], [cite:PUB00071964]].</p>\r\n\r\n<p>Three functional domains of TAP have been characterised: the RNA-binding domain, the Nuclear Transport Factor 2 (NTF2)-like domain, and the ubiquitin-associated (UBA) domain. The RNA-binding domain (RBD) of TAP is located at its amino terminus and is composed of two RNA recognition motifs (RRMs) and one leucine-rich region [[cite:PUB00071967], [cite:PUB00071968]]. Once bound to mRNA, TAP escorts the messenger ribonucleoprotein (mRNP) to the nuclear pore, where TAP interacts with nucleoporins via the NTF2-like (NTF2L) and UBA domains [[cite:PUB00026433]].</p>",
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"wikipedia": null,
"literature": {
"PUB00071961": {
"PMID": 9214641,
"ISBN": null,
"volume": "16",
"issue": "11",
"year": 1997,
"title": "Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores.",
"URL": null,
"raw_pages": "3256-71",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Segref A",
"Sharma K",
"Doye V",
"Hellwig A",
"Huber J",
"Luhrmann R",
"Hurt E."
],
"DOI_URL": "http://dx.doi.org/10.1093/emboj/16.11.3256"
},
"PUB00071967": {
"PMID": 11724776,
"ISBN": null,
"volume": "277",
"issue": "6",
"year": 2002,
"title": "U2AF participates in the binding of TAP (NXF1) to mRNA.",
"URL": null,
"raw_pages": "3935-42",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Zolotukhin AS",
"Tan W",
"Bear J",
"Smulevitch S",
"Felber BK."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M107598200"
},
"PUB00026433": {
"PMID": 11583626,
"ISBN": null,
"volume": "8",
"issue": "3",
"year": 2001,
"title": "Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor.",
"URL": null,
"raw_pages": "645-56",
"medline_journal": "Mol Cell",
"ISO_journal": "Mol. Cell",
"authors": [
"Fribourg S",
"Braun IC",
"Izaurralde E",
"Conti E."
],
"DOI_URL": "http://dx.doi.org/10.1016/S1097-2765(01)00348-3"
},
"PUB00071960": {
"PMID": 9660949,
"ISBN": null,
"volume": "1",
"issue": "5",
"year": 1998,
"title": "TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus.",
"URL": null,
"raw_pages": "649-59",
"medline_journal": "Mol Cell",
"ISO_journal": "Mol. Cell",
"authors": [
"Gruter P",
"Tabernero C",
"von Kobbe C",
"Schmitt C",
"Saavedra C",
"Bachi A",
"Wilm M",
"Felber BK",
"Izaurralde E."
],
"DOI_URL": "http://dx.doi.org/10.1016/S1097-2765(00)80065-9"
},
"PUB00071968": {
"PMID": 18364396,
"ISBN": null,
"volume": "105",
"issue": "13",
"year": 2008,
"title": "Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.",
"URL": null,
"raw_pages": "5154-9",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Hautbergue GM",
"Hung ML",
"Golovanov AP",
"Lian LY",
"Wilson SA."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.0709167105"
},
"PUB00018170": {
"PMID": 11073998,
"ISBN": null,
"volume": "20",
"issue": "23",
"year": 2000,
"title": "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.",
"URL": null,
"raw_pages": "8996-9008",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Herold A",
"Suyama M",
"Rodrigues JP",
"Braun IC",
"Kutay U",
"Carmo-Fonseca M",
"Bork P",
"Izaurralde E."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.20.23.8996-9008.2000"
},
"PUB00071964": {
"PMID": 11566096,
"ISBN": null,
"volume": "11",
"issue": "18",
"year": 2001,
"title": "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation.",
"URL": null,
"raw_pages": "1381-91",
"medline_journal": "Curr Biol",
"ISO_journal": "Curr. Biol.",
"authors": [
"Jun L",
"Frints S",
"Duhamel H",
"Herold A",
"Abad-Rodrigues J",
"Dotti C",
"Izaurralde E",
"Marynen P",
"Froyen G."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0960-9822(01)00419-5"
},
"PUB00071970": {
"PMID": 10668806,
"ISBN": null,
"volume": "6",
"issue": "1",
"year": 2000,
"title": "The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.",
"URL": null,
"raw_pages": "136-58",
"medline_journal": "RNA",
"ISO_journal": "RNA",
"authors": [
"Bachi A",
"Braun IC",
"Rodrigues JP",
"Pante N",
"Ribbeck K",
"von Kobbe C",
"Kutay U",
"Wilm M",
"Gorlich D",
"Carmo-Fonseca M",
"Izaurralde E."
],
"DOI_URL": "http://dx.doi.org/10.1017/S1355838200991994"
},
"PUB00071958": {
"PMID": 11545741,
"ISBN": null,
"volume": "8",
"issue": "2",
"year": 2001,
"title": "Two closely related human nuclear export factors utilize entirely distinct export pathways.",
"URL": null,
"raw_pages": "397-406",
"medline_journal": "Mol Cell",
"ISO_journal": "Mol. Cell",
"authors": [
"Yang J",
"Bogerd HP",
"Wang PJ",
"Page DC",
"Cullen BR."
],
"DOI_URL": "http://dx.doi.org/10.1016/S1097-2765(01)00303-3"
}
},
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"structural_models": {
"alphafold": 5201,
"bfvd": 0
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"taxa": 6608
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"is_llm": false,
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"representative_structure": {
"accession": "9i8a",
"name": "NXT1-NXF1 complex crystallized in space group P65 2 2"
}
}
}
