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{
"metadata": {
"accession": "IPR028676",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd15846": "SNARE motif of syntaxin 17"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR000727",
"name": "Target SNARE coiled-coil homology domain",
"type": "Domain",
"children": [
{
"accession": "IPR028671",
"name": "Syntaxin-2, SNARE motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR028676",
"name": "Syntaxin-17, SNARE motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR031186",
"name": "Syntaxin-3, SNARE motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR039077",
"name": "SNAP25, N-terminal SNARE motif, chordates",
"type": "Domain",
"children": []
},
{
"accession": "IPR041875",
"name": "Syntaxin-8, SNARE domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042781",
"name": "Syntaxin 11, SNARE motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR044766",
"name": "NPSN/SNAP25-like, N-terminal SNARE domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR061287",
"name": "Synaptosomal-associated protein 47, N-terminal SNARE domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR061288",
"name": "Synaptosomal-associated protein 47, C-terminal SNARE domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Syntaxin-17, SNARE motif",
"short": "STX17_SNARE"
},
"description": [
{
"text": "<p>Syntaxin-17 (STX17) belongs to the syntaxin family, which is a group of the membrane integrated proteins participating in exocytosis. Syntaxins are associated with various intracellular membrane compartments and have been implicated in various physiological processes such as axonal growth, cell division and autophagosome-lysosome fusion [[cite:PUB00101685], [cite:PUB00068996]].</p>\n\n<p>STX17 is required to maintain the architecture of ER-Golgi intermediate compartment and Golgi [[cite:PUB00068997]]. STX17 is also involved in the fusion of autophagosomes with endosomes/lysosomes. Its unique C-terminal hairpin structure mediated by two tandem transmembrane domains is essential for its association with the autophagosomal membrane [[cite:PUB00065300], [cite:PUB00095356]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This entry represents the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) motif of STX17, which consist of coiled-coil helices.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00068996": {
"PMID": 18691641,
"ISBN": null,
"volume": "423",
"issue": "2",
"year": 2008,
"title": "Nuclear localization of a novel human syntaxin 1B isoform.",
"URL": null,
"raw_pages": "160-71",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Pereira S",
"Massacrier A",
"Roll P",
"Verine A",
"Etienne-Grimaldi MC",
"Poitelon Y",
"Robaglia-Schlupp A",
"Jamali S",
"Roeckel-Trevisiol N",
"Royer B",
"Pontarotti P",
"Leveque C",
"Seagar M",
"Levy N",
"Cau P",
"Szepetowski P."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.gene.2008.07.010"
},
"PUB00068997": {
"PMID": 21545355,
"ISBN": null,
"volume": "103",
"issue": "7",
"year": 2011,
"title": "Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi.",
"URL": null,
"raw_pages": "333-50",
"medline_journal": "Biol Cell",
"ISO_journal": "Biol. Cell",
"authors": [
"Muppirala M",
"Gupta V",
"Swarup G."
],
"DOI_URL": "http://dx.doi.org/10.1042/BC20110006"
},
"PUB00065300": {
"PMID": 23217709,
"ISBN": null,
"volume": "151",
"issue": "6",
"year": 2012,
"title": "The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes.",
"URL": null,
"raw_pages": "1256-69",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Itakura E",
"Kishi-Itakura C",
"Mizushima N."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.cell.2012.11.001"
},
"PUB00101685": {
"PMID": 23466629,
"ISBN": null,
"volume": "9",
"issue": "6",
"year": 2013,
"title": "Syntaxin 17: the autophagosomal SNARE.",
"URL": null,
"raw_pages": "917-9",
"medline_journal": "Autophagy",
"ISO_journal": "Autophagy",
"authors": [
"Itakura E",
"Mizushima N."
],
"DOI_URL": null
},
"PUB00095356": {
"PMID": 25686604,
"ISBN": null,
"volume": "520",
"issue": "7548",
"year": 2015,
"title": "ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.",
"URL": null,
"raw_pages": "563-6",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Diao J",
"Liu R",
"Rong Y",
"Zhao M",
"Zhang J",
"Lai Y",
"Zhou Q",
"Wilz LM",
"Li J",
"Vivona S",
"Pfuetzner RA",
"Brunger AT",
"Zhong Q."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR010989",
"name": "SNARE",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 954,
"pathways": 4,
"proteins": 954,
"proteomes": 761,
"sets": 0,
"structural_models": {
"alphafold": 884,
"bfvd": 0
},
"structures": 1,
"taxa": 2439
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
