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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR027290",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0005018",
"name": "platelet-derived growth factor alpha-receptor activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0048008",
"name": "platelet-derived growth factor receptor signaling pathway",
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"accession": "IPR027290",
"name": "Platelet-derived growth factor receptor alpha",
"type": "Family",
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},
"name": {
"name": "Platelet-derived growth factor receptor alpha",
"short": "PDGFRA"
},
"description": [
{
"text": "<p>Platelet-derived growth factor (PDGF) is a growth factor that plays a significant role in cell proliferation and embryonic develpment. It is regulated through the platelet-derived growth factor receptor (PDGFR), a tyrosine kinase (RTK) [[cite:PUB00063696]]. There are two types of PDGFR: alpha and beta. This entry represents the alpha type PDGFR (PDGFRA).</p>",
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"title": "PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.",
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"medline_journal": "Nat Cell Biol",
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"Bergsten E",
"Uutela M",
"Li X",
"Pietras K",
"Ostman A",
"Heldin CH",
"Alitalo K",
"Eriksson U."
],
"DOI_URL": "http://dx.doi.org/10.1038/35074588"
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"volume": "299",
"issue": "5607",
"year": 2003,
"title": "PDGFRA activating mutations in gastrointestinal stromal tumors.",
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"raw_pages": "708-10",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Heinrich MC",
"Corless CL",
"Duensing A",
"McGreevey L",
"Chen CJ",
"Joseph N",
"Singer S",
"Griffith DJ",
"Haley A",
"Town A",
"Demetri GD",
"Fletcher CD",
"Fletcher JA."
],
"DOI_URL": "http://dx.doi.org/10.1126/science.1079666"
},
"PUB00063721": {
"PMID": 15928335,
"ISBN": null,
"volume": "23",
"issue": "23",
"year": 2005,
"title": "PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib.",
"URL": null,
"raw_pages": "5357-64",
"medline_journal": "J Clin Oncol",
"ISO_journal": "J. Clin. Oncol.",
"authors": [
"Corless CL",
"Schroeder A",
"Griffith D",
"Town A",
"McGreevey L",
"Harrell P",
"Shiraga S",
"Bainbridge T",
"Morich J",
"Heinrich MC."
],
"DOI_URL": "http://dx.doi.org/10.1200/JCO.2005.14.068"
},
"PUB00063696": {
"PMID": 1653029,
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"issue": "6",
"year": 1991,
"title": "Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit.",
"URL": null,
"raw_pages": "413-25",
"medline_journal": "Cell Regul",
"ISO_journal": "Cell Regul.",
"authors": [
"Kazlauskas A",
"Durden DL",
"Cooper JA."
],
"DOI_URL": null
},
"PUB00063697": {
"PMID": 1709159,
"ISBN": null,
"volume": "266",
"issue": "14",
"year": 1991,
"title": "Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation.",
"URL": null,
"raw_pages": "8987-92",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Kelly JD",
"Haldeman BA",
"Grant FJ",
"Murray MJ",
"Seifert RA",
"Bowen-Pope DF",
"Cooper JA",
"Kazlauskas A."
],
"DOI_URL": null
},
"PUB00063698": {
"PMID": 11331882,
"ISBN": null,
"volume": "3",
"issue": "5",
"year": 2001,
"title": "PDGF-D, a new protease-activated growth factor.",
"URL": null,
"raw_pages": "517-21",
"medline_journal": "Nat Cell Biol",
"ISO_journal": "Nat. Cell Biol.",
"authors": [
"LaRochelle WJ",
"Jeffers M",
"McDonald WF",
"Chillakuru RA",
"Giese NA",
"Lokker NA",
"Sullivan C",
"Boldog FL",
"Yang M",
"Vernet C",
"Burgess CE",
"Fernandes E",
"Deegler LL",
"Rittman B",
"Shimkets J",
"Shimkets RA",
"Rothberg JM",
"Lichenstein HS."
],
"DOI_URL": "http://dx.doi.org/10.1038/35074593"
},
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"PMID": 1396585,
"ISBN": null,
"volume": "11",
"issue": "11",
"year": 1992,
"title": "Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma.",
"URL": null,
"raw_pages": "3911-9",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Ronnstrand L",
"Mori S",
"Arridsson AK",
"Eriksson A",
"Wernstedt C",
"Hellman U",
"Claesson-Welsh L",
"Heldin CH."
],
"DOI_URL": null
},
"PUB00063710": {
"PMID": 1314164,
"ISBN": null,
"volume": "11",
"issue": "4",
"year": 1992,
"title": "Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.",
"URL": null,
"raw_pages": "1373-82",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Kashishian A",
"Kazlauskas A",
"Cooper JA."
],
"DOI_URL": null
},
"PUB00063719": {
"PMID": 20972453,
"ISBN": null,
"volume": "30",
"issue": "8",
"year": 2011,
"title": "The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro.",
"URL": null,
"raw_pages": "933-43",
"medline_journal": "Oncogene",
"ISO_journal": "Oncogene",
"authors": [
"von Bubnoff N",
"Gorantla SP",
"Engh RA",
"Oliveira TM",
"Thone S",
"Aberg E",
"Peschel C",
"Duyster J."
],
"DOI_URL": "http://dx.doi.org/10.1038/onc.2010.476"
},
"PUB00063718": {
"PMID": 12808148,
"ISBN": null,
"volume": "100",
"issue": "13",
"year": 2003,
"title": "Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome.",
"URL": null,
"raw_pages": "7830-5",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Griffin JH",
"Leung J",
"Bruner RJ",
"Caligiuri MA",
"Briesewitz R."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.0932698100"
},
"PUB00063717": {
"PMID": 8586421,
"ISBN": null,
"volume": "30",
"issue": "2",
"year": 1995,
"title": "Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA.",
"URL": null,
"raw_pages": "224-32",
"medline_journal": "Genomics",
"ISO_journal": "Genomics",
"authors": [
"Kawagishi J",
"Kumabe T",
"Yoshimoto T",
"Yamamoto T."
],
"DOI_URL": "http://dx.doi.org/10.1006/geno.1995.9883"
},
"PUB00063713": {
"PMID": 17656670,
"ISBN": null,
"volume": "27",
"issue": "10",
"year": 2007,
"title": "Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro.",
"URL": null,
"raw_pages": "2142-9",
"medline_journal": "Arterioscler Thromb Vasc Biol",
"ISO_journal": "Arterioscler. Thromb. Vasc. Biol.",
"authors": [
"Magnusson PU",
"Looman C",
"Ahgren A",
"Wu Y",
"Claesson-Welsh L",
"Heuchel RL."
],
"DOI_URL": "http://dx.doi.org/10.1161/01.ATV.0000282198.60701.94"
},
"PUB00063712": {
"PMID": 1313434,
"ISBN": null,
"volume": "267",
"issue": "9",
"year": 1992,
"title": "Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.",
"URL": null,
"raw_pages": "6429-34",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Mori S",
"Heldin CH",
"Claesson-Welsh L."
],
"DOI_URL": null
},
"PUB00063709": {
"PMID": 1846866,
"ISBN": null,
"volume": "112",
"issue": "3",
"year": 1991,
"title": "Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor.",
"URL": null,
"raw_pages": "469-78",
"medline_journal": "J Cell Biol",
"ISO_journal": "J. Cell Biol.",
"authors": [
"Sorkin A",
"Westermark B",
"Heldin CH",
"Claesson-Welsh L."
],
"DOI_URL": "http://dx.doi.org/10.1083/jcb.112.3.469"
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"PUB00063706": {
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"ISBN": null,
"volume": "51",
"issue": "1",
"year": 2012,
"title": "Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm.",
"URL": null,
"raw_pages": "54-65",
"medline_journal": "Genes Chromosomes Cancer",
"ISO_journal": "Genes Chromosomes Cancer",
"authors": [
"Chmielecki J",
"Peifer M",
"Viale A",
"Hutchinson K",
"Giltnane J",
"Socci ND",
"Hollis CJ",
"Dean RS",
"Yenamandra A",
"Jagasia M",
"Kim AS",
"Dave UP",
"Thomas RK",
"Pao W."
],
"DOI_URL": "http://dx.doi.org/10.1002/gcc.20930"
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"PUB00063705": {
"PMID": 9285559,
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"volume": "15",
"issue": "9",
"year": 1997,
"title": "Integration of proviral DNA into the PDGF beta-receptor gene in HTLV-I-infected T-cells results in a novel tyrosine kinase product with transforming activity.",
"URL": null,
"raw_pages": "1051-7",
"medline_journal": "Oncogene",
"ISO_journal": "Oncogene",
"authors": [
"Chi KD",
"McPhee RA",
"Wagner AS",
"Dietz JJ",
"Pantazis P",
"Goustin AS."
],
"DOI_URL": "http://dx.doi.org/10.1038/sj.onc.1201267"
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"PUB00063708": {
"PMID": 2554309,
"ISBN": null,
"volume": "86",
"issue": "21",
"year": 1989,
"title": "Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.",
"URL": null,
"raw_pages": "8314-8",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Matsui T",
"Pierce JH",
"Fleming TP",
"Greenberger JS",
"LaRochelle WJ",
"Ruggiero M",
"Aaronson SA."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.86.21.8314"
},
"PUB00063707": {
"PMID": 2550144,
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"volume": "58",
"issue": "6",
"year": 1989,
"title": "Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins.",
"URL": null,
"raw_pages": "1121-33",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Kazlauskas A",
"Cooper JA."
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"DOI_URL": "http://dx.doi.org/10.1016/0092-8674(89)90510-2"
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