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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR027128",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0005164",
"name": "tumor necrosis factor receptor binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0001817",
"name": "regulation of cytokine production",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0008063",
"name": "Toll signaling pathway",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0033209",
"name": "tumor necrosis factor-mediated signaling pathway",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0045087",
"name": "innate immune response",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0050688",
"name": "regulation of defense response to virus",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd16640": "RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001841",
"name": "Zinc finger, RING-type",
"type": "Domain",
"children": [
{
"accession": "IPR018957",
"name": "Zinc finger, C3HC4 RING-type",
"type": "Domain",
"children": [
{
"accession": "IPR045859",
"name": "Peroxisome biogenesis factor 2, HC subclass-RING finger domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR058558",
"name": "V(D)J recombination-activating protein 1, RING finger, HC subclass",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR024766",
"name": "Zinc finger, RING-H2-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR024991",
"name": "Anaphase-promoting complex subunit 11, RING-H2 finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR027133",
"name": "TNF receptor-associated factor 2, C3HC3D-type RING zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR027139",
"name": "TNF receptor-associated factor 6, C3HC3D-type RING zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR027370",
"name": "Zinc finger, RING-type, eukaryotic",
"type": "Domain",
"children": [
{
"accession": "IPR027726",
"name": "E3 ubiquitin-protein ligase Trim36, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR033491",
"name": "Probable E3 ubiquitin-protein ligase MID2, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042667",
"name": "E3 ubiquitin-protein ligase TRIM63, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042716",
"name": "E3 ubiquitin-protein ligase RNF114, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042752",
"name": "TRIM54, RING finger, HC subclass",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR027934",
"name": "Cellulose synthase, RING-type zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR028511",
"name": "E3 ubiquitin-protein ligase SH3RF2, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR032043",
"name": "E3 ubiquitin-protein ligase Msl2, zinc RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR033609",
"name": "E3 ubiquitin-protein ligase RNF152, RING finger domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035691",
"name": "ORC ubiquitin ligase 1, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR039503",
"name": "BARD1, Zinc finger, RING-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR039520",
"name": "E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR039571",
"name": "RNF126, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR039804",
"name": "Listerin, zinc finger, RING-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR040089",
"name": "RNF26, C3HC5-type zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR040100",
"name": "RING finger protein 208, HC type RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR040178",
"name": "E3 ubiquitin-protein ligase RNF220, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR040380",
"name": "HAKAI-like, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR041888",
"name": "ZN598/HEL22, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR042656",
"name": "E3 ubiquitin-protein ligase TRIM68, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042699",
"name": "E3 ubiquitin-protein ligase TRIM58, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042712",
"name": "E3 ubiquitin-protein ligase RNF149, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042713",
"name": "TIF1-beta, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042741",
"name": "RING1 , RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042765",
"name": "TRIM42, RING-HC finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR042784",
"name": "TRIM10, RING-HC finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR042823",
"name": "E3 ubiquitin-protein ligase Dma1/Dma2, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042843",
"name": "DTX3L, RING-HC finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR043295",
"name": "RNF4, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR043400",
"name": "RNF141, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR044080",
"name": "MDM2, modified RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR044110",
"name": "RNF146, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR045195",
"name": "LOG2-like, modified RING finger, C3HC5-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR045317",
"name": "E3 ubiquitin-protein ligase RGLG1/2, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR045903",
"name": "E3 ubiquitin-protein ligase ZNRF3, zinc finger, RING-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR045907",
"name": "E3 ubiquitin-protein ligase RNF43, Zinc finger, RING-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR047243",
"name": "BRCA1-associated protein, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047466",
"name": "E3 ubiquitin-protein ligase UHRF2, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047498",
"name": "E3 ubiquitin-protein ligase ORTHRUS 1/2-like, first RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047529",
"name": "E3 ubiquitin-protein ligase ORTHRUS 1-5, second RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047559",
"name": "Heme-oxidized IRP2 ubiquitin ligase 1, modified RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047563",
"name": "Ankyrin repeat and IBR domain-containing protein 1, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047823",
"name": "RNF145, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047986",
"name": "E3 ubiquitin-protein ligase RNF182, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR048025",
"name": "RING finger protein 24, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR048217",
"name": "RING-type E3 ubiquitin transferase BIG BROTHER, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR049440",
"name": "TNF receptor-associated factor 3/5, RING domain",
"type": "Domain",
"children": [
{
"accession": "IPR027128",
"name": "TNF receptor-associated factor 3, C3HC3D-type RING zinc finger",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR049548",
"name": "E3 ubiquitin-protein ligase Sina-like, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR056760",
"name": "E3 ubiquitin-protein ligase XB3-like, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR056939",
"name": "Vps8, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR058051",
"name": "Synoviolin-like, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR058746",
"name": "Topors, zinc finger, RING-type",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "TNF receptor-associated factor 3, C3HC3D-type RING zinc finger",
"short": "TRAF3_RING-HC"
},
"description": [
{
"text": "<p>Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein (MAP) kinase activation and non-canonical nuclear factor-kB signalling [[cite:PUB00062969]]. It is a critical regulator of both innate and adaptive immune responses [[cite:PUB00062976]]. TRAF3 plays a role in the regulation of B-cell survival [[cite:PUB00062975]], in the regulation of antiviral responses [[cite:PUB00062973]], and in T-cell dependent immune responses [[cite:PUB00062978]]. It is required for normal antibody isotype switching from IgM to IgG [[cite:PUB00062979]]. Differences in the ubiquitination of TRAF3 are the key to the selective production of type I interferons versus proinflammatory cytokines [[cite:PUB00062980]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This entry represents the modified C3HC3D-type (HC subclass) RING zinc finger of TRAF3.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00062980": {
"PMID": 19898473,
"ISBN": null,
"volume": "11",
"issue": "1",
"year": 2010,
"title": "Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.",
"URL": null,
"raw_pages": "70-5",
"medline_journal": "Nat Immunol",
"ISO_journal": "Nat. Immunol.",
"authors": [
"Tseng PH",
"Matsuzawa A",
"Zhang W",
"Mino T",
"Vignali DA",
"Karin M."
],
"DOI_URL": "http://dx.doi.org/10.1038/ni.1819"
},
"PUB00062969": {
"PMID": 21660053,
"ISBN": null,
"volume": "11",
"issue": "7",
"year": 2011,
"title": "Expanding TRAF function: TRAF3 as a tri-faced immune regulator.",
"URL": null,
"raw_pages": "457-68",
"medline_journal": "Nat Rev Immunol",
"ISO_journal": "Nat. Rev. Immunol.",
"authors": [
"Hacker H",
"Tseng PH",
"Karin M."
],
"DOI_URL": "http://dx.doi.org/10.1038/nri2998"
},
"PUB00062973": {
"PMID": 16306936,
"ISBN": null,
"volume": "439",
"issue": "7073",
"year": 2006,
"title": "Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response.",
"URL": null,
"raw_pages": "208-11",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Oganesyan G",
"Saha SK",
"Guo B",
"He JQ",
"Shahangian A",
"Zarnegar B",
"Perry A",
"Cheng G."
],
"DOI_URL": "http://dx.doi.org/10.1038/nature04374"
},
"PUB00062978": {
"PMID": 8934568,
"ISBN": null,
"volume": "5",
"issue": "5",
"year": 1996,
"title": "Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.",
"URL": null,
"raw_pages": "407-15",
"medline_journal": "Immunity",
"ISO_journal": "Immunity",
"authors": [
"Xu Y",
"Cheng G",
"Baltimore D."
],
"DOI_URL": "http://dx.doi.org/10.1016/S1074-7613(00)80497-5"
},
"PUB00062976": {
"PMID": 17633016,
"ISBN": null,
"volume": "597",
"issue": null,
"year": 2007,
"title": "TRAF3 and its biological function.",
"URL": null,
"raw_pages": "48-59",
"medline_journal": "Adv Exp Med Biol",
"ISO_journal": "Adv. Exp. Med. Biol.",
"authors": [
"He JQ",
"Oganesyan G",
"Saha SK",
"Zarnegar B",
"Cheng G."
],
"DOI_URL": null
},
"PUB00062975": {
"PMID": 18313334,
"ISBN": null,
"volume": "28",
"issue": "3",
"year": 2008,
"title": "TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.",
"URL": null,
"raw_pages": "391-401",
"medline_journal": "Immunity",
"ISO_journal": "Immunity",
"authors": [
"Gardam S",
"Sierro F",
"Basten A",
"Mackay F",
"Brink R."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.immuni.2008.01.009"
},
"PUB00062979": {
"PMID": 19228877,
"ISBN": null,
"volume": "21",
"issue": "4",
"year": 2009,
"title": "TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.",
"URL": null,
"raw_pages": "477-88",
"medline_journal": "Int Immunol",
"ISO_journal": "Int. Immunol.",
"authors": [
"Jabara HH",
"Weng Y",
"Sannikova T",
"Geha RS."
],
"DOI_URL": "http://dx.doi.org/10.1093/intimm/dxp013"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR013083",
"name": "Zinc finger, RING/FYVE/PHD-type",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 1197,
"pathways": 17,
"proteins": 1197,
"proteomes": 661,
"sets": 0,
"structural_models": {
"alphafold": 1117,
"bfvd": 0
},
"structures": 0,
"taxa": 2103
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
