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{
"metadata": {
"accession": "IPR026465",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"ncbifam": {
"TIGR04224": "serine-rich repeat glycoprotein adhesin accessory Sec interaction domain"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR026465",
"name": "Serine-rich repeat adhesion glycoprotein, N-terminal domain",
"type": "Domain",
"children": []
},
"name": {
"name": "Serine-rich repeat adhesion glycoprotein, N-terminal domain",
"short": "Ser_adhes_glycop_N"
},
"description": [
{
"text": "<p>This entry represents a conserved N-terminal domain shared by highly repetitive Streptococcal serine-rich adhesion glycoproteins that may exceed 4000 amino acids in length, consisting largely of long regions in which every second amino acid is Ser. Members of this family normally begin with a KxYKxGKxW motif region ([interpro:IPR022263]) and end with an LPXTG motif region. Members are exported by the accessory secretory system (SecA2 and SecY2). They are highly variable among the Streptococci and may help determine host ranges for pathogenesis [[cite:PUB00060490]].</p>\n\n<p>Some of the proteins belonging to this entry are: Platelet binding protein GspB from Streptococcus gordonii, which plays a role in virulence, biofilm formation and host-pathogen interactions [[cite:PUB00058921], [cite:PUB00150953]]; Streptococcal hemagglutinin from Streptococcus gordonii (Hsa), a cell wall protein involved with PadA in host cell interactions required for colonization and pathogensis (Probable) [[cite:PUB00150951], [cite:PUB00150952]]; and Fap1 adhesin from Streptococcus parasanguinis, the major structural element of fimbriae, required for adherence to saliva-coated hydroxyapatite beads (SHA), an in vitro tooth model [[cite:PUB00150954]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00058921": {
"PMID": 21765814,
"ISBN": null,
"volume": "7",
"issue": "7",
"year": 2011,
"title": "A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors.",
"URL": null,
"raw_pages": "e1002112",
"medline_journal": "PLoS Pathog",
"ISO_journal": "PLoS Pathog.",
"authors": [
"Pyburn TM",
"Bensing BA",
"Xiong YQ",
"Melancon BJ",
"Tomasiak TM",
"Ward NJ",
"Yankovskaya V",
"Oliver KM",
"Cecchini G",
"Sulikowski GA",
"Tyska MJ",
"Sullam PM",
"Iverson TM."
],
"DOI_URL": "http://dx.doi.org/10.1371/journal.ppat.1002112"
},
"PUB00150952": {
"PMID": 27616700,
"ISBN": null,
"volume": "19",
"issue": "1",
"year": 2017,
"title": "Concerted functions of Streptococcus gordonii surface proteins PadA and Hsa mediate activation of human platelets and interactions with extracellular matrix. ",
"URL": null,
"raw_pages": null,
"medline_journal": "Cell Microbiol",
"ISO_journal": "Cell Microbiol",
"authors": [
"Haworth JA",
"Jenkinson HF",
"Petersen HJ",
"Back CR",
"Brittan JL",
"Kerrigan SW",
"Nobbs AH."
],
"DOI_URL": null
},
"PUB00150953": {
"PMID": 20714350,
"ISBN": null,
"volume": "6",
"issue": "8",
"year": 2010,
"title": "The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms.",
"URL": null,
"raw_pages": "e1001044",
"medline_journal": "PLoS Pathog",
"ISO_journal": "PLoS Pathog",
"authors": [
"Sanchez CJ",
"Shivshankar P",
"Stol K",
"Trakhtenbroit S",
"Sullam PM",
"Sauer K",
"Hermans PW",
"Orihuela CJ."
],
"DOI_URL": null
},
"PUB00150951": {
"PMID": 19884334,
"ISBN": null,
"volume": "78",
"issue": "1",
"year": 2010,
"title": "Human platelets recognize a novel surface protein, PadA, on Streptococcus gordonii through a unique interaction involving fibrinogen receptor GPIIbIIIa.",
"URL": null,
"raw_pages": "413-22",
"medline_journal": "Infect Immun",
"ISO_journal": "Infect Immun",
"authors": [
"Petersen HJ",
"Keane C",
"Jenkinson HF",
"Vickerman MM",
"Jesionowski A",
"Waterhouse JC",
"Cox D",
"Kerrigan SW."
],
"DOI_URL": null
},
"PUB00150954": {
"PMID": 10594831,
"ISBN": null,
"volume": "34",
"issue": "5",
"year": 1999,
"title": "Identification of dipeptide repeats and a cell wall sorting signal in the fimbriae-associated adhesin, Fap1, of Streptococcus parasanguis.",
"URL": null,
"raw_pages": "1070-81",
"medline_journal": "Mol Microbiol",
"ISO_journal": "Mol Microbiol",
"authors": [
"Wu H",
"Fives-Taylor PM."
],
"DOI_URL": null
},
"PUB00060490": {
"PMID": 20562303,
"ISBN": null,
"volume": "192",
"issue": "16",
"year": 2010,
"title": "Transport of preproteins by the accessory Sec system requires a specific domain adjacent to the signal peptide.",
"URL": null,
"raw_pages": "4223-32",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Bensing BA",
"Sullam PM."
],
"DOI_URL": "http://dx.doi.org/10.1128/JB.00373-10"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 224,
"pathways": 0,
"proteins": 224,
"proteomes": 38,
"sets": 0,
"structural_models": {
"alphafold": 72,
"bfvd": 0
},
"structures": 0,
"taxa": 108
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
