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{
    "metadata": {
        "accession": "IPR025725",
        "entry_id": null,
        "type": "domain",
        "go_terms": [
            {
                "identifier": "GO:0004842",
                "name": "ubiquitin-protein transferase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016567",
                "name": "protein ubiquitination",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF13979": "SopA-like catalytic domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR025725",
            "name": "E3 ubiquitin-protein ligase SopA-like, catalytic domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "E3 ubiquitin-protein ligase SopA-like, catalytic domain",
            "short": "SopA-like_cat"
        },
        "description": [
            {
                "text": "<p>This domain is found in the Escherichia coli Type III secretion effector proteins SopA and NleL [[cite:PUB00057922], [cite:PUB00049190]]. These proteins have been shown to act as E3 ubiquitin ligase enzymes. This domain contains the active site cysteine residue.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00057922": {
                "PMID": 20980253,
                "ISBN": null,
                "volume": "286",
                "issue": "1",
                "year": 2011,
                "title": "Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia coli O157:H7.",
                "URL": null,
                "raw_pages": "441-9",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Lin DY",
                    "Diao J",
                    "Zhou D",
                    "Chen J."
                ],
                "DOI_URL": "http://dx.doi.org/10.1074/jbc.M110.167643"
            },
            "PUB00049190": {
                "PMID": 18066077,
                "ISBN": null,
                "volume": "15",
                "issue": "1",
                "year": 2008,
                "title": "Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase.",
                "URL": null,
                "raw_pages": "65-70",
                "medline_journal": "Nat Struct Mol Biol",
                "ISO_journal": "Nat. Struct. Mol. Biol.",
                "authors": [
                    "Diao J",
                    "Zhang Y",
                    "Huibregtse JM",
                    "Zhou D",
                    "Chen J."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/nsmb1346"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR038270",
                "name": "SopA-like, catalytic domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 20,
            "interactions": 0,
            "matches": 1093,
            "pathways": 1,
            "proteins": 1093,
            "proteomes": 40,
            "sets": 0,
            "structural_models": {
                "alphafold": 1061,
                "bfvd": 0
            },
            "structures": 9,
            "taxa": 337
        },
        "entry_annotations": {
            "alignment:seed": 21,
            "alignment:full": 36
        },
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "2.3.2.26",
                        "url": "https://enzyme.expasy.org/EC/2.3.2.26"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "8st7",
            "name": "Structure of E3 ligase VsHECT bound to ubiquitin"
        }
    }
}