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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR025655",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0005515",
"name": "protein binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016560",
"name": "protein import into peroxisome matrix, docking",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005778",
"name": "peroxisomal membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"panther": {
"PTHR23058": "PEROXISOMAL MEMBRANE PROTEIN PEX14"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR025655",
"name": "Peroxisomal membrane protein 14",
"type": "Family",
"children": []
},
"name": {
"name": "Peroxisomal membrane protein 14",
"short": "PEX14"
},
"description": [
{
"text": "<p>Peroxisomal membrane protein PEX14, or peroxin-14, is a core component of the peroxisomal translocation machinery or importomer [[cite:PUB00055948], [cite:PUB00050069]]. PEX14 is involved in the docking of PEX5-bound protein onto the peroxisomal membrane, and it may be involved in the translocation step into the peroxisome matrix [[cite:PUB00068179]]. In addition to its role in protein docking, a role in transcriptional regulation has also been suggested for PEX14 [[cite:PUB00057430]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00055948": {
"PMID": 10704444,
"ISBN": null,
"volume": "148",
"issue": "5",
"year": 2000,
"title": "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.",
"URL": null,
"raw_pages": "931-44",
"medline_journal": "J Cell Biol",
"ISO_journal": "J. Cell Biol.",
"authors": [
"Sacksteder KA",
"Jones JM",
"South ST",
"Li X",
"Liu Y",
"Gould SJ."
],
"DOI_URL": "http://dx.doi.org/10.1083/jcb.148.5.931"
},
"PUB00050069": {
"PMID": 19197237,
"ISBN": null,
"volume": "28",
"issue": "6",
"year": 2009,
"title": "Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.",
"URL": null,
"raw_pages": "745-54",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Neufeld C",
"Filipp FV",
"Simon B",
"Neuhaus A",
"Schuller N",
"David C",
"Kooshapur H",
"Madl T",
"Erdmann R",
"Schliebs W",
"Wilmanns M",
"Sattler M."
],
"DOI_URL": "http://dx.doi.org/10.1038/emboj.2009.7"
},
"PUB00057430": {
"PMID": 11863372,
"ISBN": null,
"volume": "79",
"issue": "3",
"year": 2002,
"title": "NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor.",
"URL": null,
"raw_pages": "423-31",
"medline_journal": "Genomics",
"ISO_journal": "Genomics",
"authors": [
"Gavva NR",
"Wen SC",
"Daftari P",
"Moniwa M",
"Yang WM",
"Yang-Feng LP",
"Seto E",
"Davie JR",
"Shen CK."
],
"DOI_URL": "http://dx.doi.org/10.1006/geno.2002.6714"
},
"PUB00068179": {
"PMID": 17046076,
"ISBN": null,
"volume": "1763",
"issue": "12",
"year": 2006,
"title": "Pex14p, more than just a docking protein.",
"URL": null,
"raw_pages": "1574-84",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim. Biophys. Acta",
"authors": [
"Azevedo JE",
"Schliebs W."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.bbamcr.2006.09.002"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 6050,
"pathways": 18,
"proteins": 6050,
"proteomes": 2987,
"sets": 0,
"structural_models": {
"alphafold": 5410,
"bfvd": 0
},
"structures": 19,
"taxa": 8431
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "5aon",
"name": "Crystal structure of the conserved N-terminal domain of Pex14 from Trypanosoma brucei"
}
}
}
