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{
    "metadata": {
        "accession": "IPR025521",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF14365": "Neprosin activation peptide"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR025521",
            "name": "Neprosin activation peptide",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Neprosin activation peptide",
            "short": "Neprosin_propep"
        },
        "description": [
            {
                "text": "<p>Pitcher plants are insectivorous and secrete a digestive fluid into the pitcher. This fluid contains a mixture of enzymes, including peptidases.  One of these is neprosin, characterised by the pitcher plant Nepenthes ventrata. Neprosin is a glutamic endopeptidase that preferentially cleaves peptide bonds on the C-terminal side of proline residues [[cite:PUB00081922], [cite:PUB00151162], [cite:PUB00151161]]. In contrast to most proline-cleaving enzymes, it effectively degrades proteins of any size [[cite:PUB00151161]]. The peptidase is secreted and is presumed to possess an N-terminal activation peptide [[cite:PUB00081922]] which is represented in this entry.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00151162": {
                "PMID": 35915115,
                "ISBN": null,
                "volume": "13",
                "issue": "1",
                "year": 2022,
                "title": "Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy.",
                "URL": null,
                "raw_pages": "4446",
                "medline_journal": "Nat Commun",
                "ISO_journal": "Nat Commun",
                "authors": [
                    "Del Amo-Maestro L",
                    "Mendes SR",
                    "Rodriguez-Banqueri A",
                    "Garzon-Flores L",
                    "Girbal M",
                    "Rodriguez-Lagunas MJ",
                    "Guevara T",
                    "Franch A",
                    "Perez-Cano FJ",
                    "Eckhard U",
                    "Gomis-Ruth FX."
                ],
                "DOI_URL": null
            },
            "PUB00151161": {
                "PMID": 28404794,
                "ISBN": null,
                "volume": "16",
                "issue": "6",
                "year": 2017,
                "title": "Neprosin, a Selective Prolyl Endoprotease for Bottom-up Proteomics and Histone Mapping.",
                "URL": null,
                "raw_pages": "1162-1171",
                "medline_journal": "Mol Cell Proteomics",
                "ISO_journal": "Mol Cell Proteomics",
                "authors": [
                    "Schrader CU",
                    "Lee L",
                    "Rey M",
                    "Sarpe V",
                    "Man P",
                    "Sharma S",
                    "Zabrouskov V",
                    "Larsen B",
                    "Schriemer DC."
                ],
                "DOI_URL": null
            },
            "PUB00081922": {
                "PMID": 27481162,
                "ISBN": null,
                "volume": "6",
                "issue": null,
                "year": 2016,
                "title": "Addressing proteolytic efficiency in enzymatic degradation therapy for celiac disease.",
                "URL": null,
                "raw_pages": "30980",
                "medline_journal": "Sci Rep",
                "ISO_journal": "Sci Rep",
                "authors": [
                    "Rey M",
                    "Yang M",
                    "Lee L",
                    "Zhang Y",
                    "Sheff JG",
                    "Sensen CW",
                    "Mrazek H",
                    "Halada P",
                    "Man P",
                    "McCarville JL",
                    "Verdu EF",
                    "Schriemer DC."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/srep30980"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 178,
            "interactions": 0,
            "matches": 9466,
            "pathways": 0,
            "proteins": 9197,
            "proteomes": 363,
            "sets": 0,
            "structural_models": {
                "alphafold": 7860,
                "bfvd": 0
            },
            "structures": 3,
            "taxa": 1086
        },
        "entry_annotations": {
            "alignment:seed": 82,
            "alignment:full": 5033
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}