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{
    "metadata": {
        "accession": "IPR024970",
        "entry_id": null,
        "type": "domain",
        "go_terms": [
            {
                "identifier": "GO:0060964",
                "name": "regulation of miRNA-mediated gene silencing",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF13017": "piRNA pathway germ-plasm component"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR024970",
            "name": "Maelstrom domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Maelstrom domain",
            "short": "Maelstrom"
        },
        "description": [
            {
                "text": "<p>Maelstrom is a germ-plasm component protein that is involved in the piRNA pathway, though its precise function is not known. This protein contains a novel domain, known as the Maelstrom domain, which adopts the RNaseH fold. Maelstrom is essential for Piwi-mediated silencing and acts downstream of or in parallel to H3K9me3 in Drosophila [[cite:PUB00085036]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00085036": {
                "PMID": 23159368,
                "ISBN": null,
                "volume": "151",
                "issue": "5",
                "year": 2012,
                "title": "Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression.",
                "URL": null,
                "raw_pages": "964-80",
                "medline_journal": "Cell",
                "ISO_journal": "Cell",
                "authors": [
                    "Sienski G",
                    "Donertas D",
                    "Brennecke J."
                ],
                "DOI_URL": "https://doi.org/10.1016/j.cell.2012.10.040"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 38,
            "interactions": 0,
            "matches": 1552,
            "pathways": 1,
            "proteins": 1522,
            "proteomes": 677,
            "sets": 0,
            "structural_models": {
                "alphafold": 1381,
                "bfvd": 0
            },
            "structures": 6,
            "taxa": 2607
        },
        "entry_annotations": {
            "alignment:seed": 18,
            "alignment:full": 963
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "4ybg",
            "name": "Crystal structure of the MAEL domain of Drosophila melanogaster Maelstrom"
        }
    }
}