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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR024172",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0070566",
"name": "adenylyltransferase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0046677",
"name": "response to antibiotic",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"pirsf": {
"PIRSF000819": "Predicted streptomycin 3\"-adenylyltransferase"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR024172",
"name": "Adenylyltransferase AadA/Aad9",
"type": "Family",
"children": []
},
"name": {
"name": "Adenylyltransferase AadA/Aad9",
"short": "AadA/Aad9"
},
"description": [
{
"text": "<p>This family includes aminoglycoside (3'') (9) adenylyltransferase AadA and spectinomycin 9-adenylyltransferase Aad9. AadA mediates bacterial resistance to the antibiotics streptomycin and spectinomycin [[cite:PUB00055619], [cite:PUB00094231]], while Aad9 mediates bacterial resistance to the antibiotic spectinomycin [[cite:PUB00094230]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00055619": {
"PMID": 2986186,
"ISBN": null,
"volume": "13",
"issue": "1",
"year": 1985,
"title": "Nucleotide sequence analysis of a gene encoding a streptomycin/spectinomycin adenylyltransferase.",
"URL": null,
"raw_pages": "17-30",
"medline_journal": "Plasmid",
"ISO_journal": "Plasmid",
"authors": [
"Hollingshead S",
"Vapnek D."
],
"DOI_URL": "http://dx.doi.org/10.1016/0147-619X(85)90052-6"
},
"PUB00094231": {
"PMID": 2997737,
"ISBN": null,
"volume": "13",
"issue": "19",
"year": 1985,
"title": "Nucleotide sequence of the transposon Tn7 gene encoding an aminoglycoside-modifying enzyme, 3\"(9)-O-nucleotidyltransferase.",
"URL": null,
"raw_pages": "7095-106",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res.",
"authors": [
"Fling ME",
"Kopf J",
"Richards C."
],
"DOI_URL": null
},
"PUB00094230": {
"PMID": 2993813,
"ISBN": null,
"volume": "200",
"issue": "1",
"year": 1985,
"title": "Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3\") (9).",
"URL": null,
"raw_pages": "33-9",
"medline_journal": "Mol Gen Genet",
"ISO_journal": "Mol. Gen. Genet.",
"authors": [
"Murphy E."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 2954,
"pathways": 0,
"proteins": 2954,
"proteomes": 892,
"sets": 0,
"structural_models": {
"alphafold": 2585,
"bfvd": 0
},
"structures": 6,
"taxa": 2391
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "7uy4",
"name": "Aminoglycoside-modifying enzyme ANT-3,9 in complex with spectinomycin and AMP-PNP"
}
}
}
