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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR023566",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0003755",
"name": "peptidyl-prolyl cis-trans isomerase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"pirsf": {
"PIRSF001473": "Peptidylprolyl isomerase FPR3"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR023566",
"name": "Peptidyl-prolyl cis-trans isomerase Fpr3/Fpr4-like",
"type": "Family",
"children": []
},
"name": {
"name": "Peptidyl-prolyl cis-trans isomerase Fpr3/Fpr4-like",
"short": "PPIase_Fpr3/Fpr4-like"
},
"description": [
{
"text": "<p>FK506-binding proteins (FKBPs) are a particular class of peptidyl-prolyl cis-trans isomerases (PPIases) ([ec:5.2.1.8]) [[cite:PUB00083172]]. This entry represents a group of nuclear FK506-binding proteins that act as histone chaperones. They each containing an extended acidic domain in addition to the conserved FK506-binding/peptidylprolyl isomerase (PPIase) domain. The PPIase domain has been shown to regulate histone H3 methylation, while the acidic domain has been shown to facilitate histone deposition and may regulate rDNA silencing [[cite:PUB00094164], [cite:PUB00094166]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00094164": {
"PMID": 24297734,
"ISBN": null,
"volume": "289",
"issue": "2",
"year": 2014,
"title": "Nuclear FKBPs, Fpr3 and Fpr4 affect genome-wide genes transcription.",
"URL": null,
"raw_pages": "125-36",
"medline_journal": "Mol Genet Genomics",
"ISO_journal": "Mol. Genet. Genomics",
"authors": [
"Park SK",
"Xiao H",
"Lei M."
],
"DOI_URL": null
},
"PUB00094165": {
"PMID": 20142844,
"ISBN": null,
"volume": "20",
"issue": "3",
"year": 2010,
"title": "AtFKBP53 is a histone chaperone required for repression of ribosomal RNA gene expression in Arabidopsis.",
"URL": null,
"raw_pages": "357-66",
"medline_journal": "Cell Res",
"ISO_journal": "Cell Res.",
"authors": [
"Li H",
"Luan S."
],
"DOI_URL": null
},
"PUB00094166": {
"PMID": 14981505,
"ISBN": null,
"volume": "11",
"issue": "3",
"year": 2004,
"title": "A nuclear FK506-binding protein is a histone chaperone regulating rDNA silencing.",
"URL": null,
"raw_pages": "275-83",
"medline_journal": "Nat Struct Mol Biol",
"ISO_journal": "Nat. Struct. Mol. Biol.",
"authors": [
"Kuzuhara T",
"Horikoshi M."
],
"DOI_URL": null
},
"PUB00083172": {
"PMID": 15353370,
"ISBN": null,
"volume": "9",
"issue": null,
"year": 2004,
"title": "Insights into the catalytic mechanism of peptidyl prolyl cis/trans isomerases.",
"URL": null,
"raw_pages": "3453-78",
"medline_journal": "Front Biosci",
"ISO_journal": "Front. Biosci.",
"authors": [
"Fanghanel J",
"Fischer G."
],
"DOI_URL": "http://dx.doi.org/10.2741/1494"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 2470,
"pathways": 0,
"proteins": 2470,
"proteomes": 1859,
"sets": 0,
"structural_models": {
"alphafold": 2181,
"bfvd": 0
},
"structures": 0,
"taxa": 5019
},
"entry_annotations": {},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "5.2.1.8",
"url": "https://enzyme.expasy.org/EC/5.2.1.8"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
