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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR023527",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0016772",
"name": "transferase activity, transferring phosphorus-containing groups",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"ncbifam": {
"NF006800": "histidine kinase"
},
"hamap": {
"MF_01837": "Adaptive-response sensory-kinase SasA [sasA]"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR023527",
"name": "Adaptive-response sensory-kinase SasA",
"type": "Family",
"children": []
},
"name": {
"name": "Adaptive-response sensory-kinase SasA",
"short": "Kinase_SasA"
},
"description": [
{
"text": "<p>This entry represents the adaptive-response sensory-kinase SasA family, a member of the two-component regulatory system SasA/RpaA involved in genome-wide circadian gene expression [[cite:PUB00103628]]. This family of proteins participate in the kaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with kaiC [[cite:PUB00054600]]. It is required for robustness of the circadian rhythm of gene expression and involved in clock output [[cite:PUB00103555], [cite:PUB00103629]]. The kaiABC complex has a core comprising a kaiC homohexamer, a kaiB dimer and two kaiA dimers. KaiC enhances the autophosphorylation activity of SasA, which then transfers its phosphate group to RpaA to activate it. Proteins in this entry contain a histidine kinase domain.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00103628": {
"PMID": 16882723,
"ISBN": null,
"volume": "103",
"issue": "32",
"year": 2006,
"title": "A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria.",
"URL": null,
"raw_pages": "12109-14",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Takai N",
"Nakajima M",
"Oyama T",
"Kito R",
"Sugita C",
"Sugita M",
"Kondo T",
"Iwasaki H."
],
"DOI_URL": null
},
"PUB00103629": {
"PMID": 34618577,
"ISBN": null,
"volume": "374",
"issue": "6564",
"year": 2021,
"title": "Reconstitution of an intact clock reveals mechanisms of circadian timekeeping.",
"URL": null,
"raw_pages": "eabd4453",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Chavan AG",
"Swan JA",
"Heisler J",
"Sancar C",
"Ernst DC",
"Fang M",
"Palacios JG",
"Spangler RK",
"Bagshaw CR",
"Tripathi S",
"Crosby P",
"Golden SS",
"Partch CL",
"LiWang A."
],
"DOI_URL": null
},
"PUB00103555": {
"PMID": 20133618,
"ISBN": null,
"volume": "107",
"issue": "7",
"year": 2010,
"title": "Three major output pathways from the KaiABC-based oscillator cooperate to generate robust circadian kaiBC expression in cyanobacteria.",
"URL": null,
"raw_pages": "3263-8",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Taniguchi Y",
"Takai N",
"Katayama M",
"Kondo T",
"Oyama T."
],
"DOI_URL": null
},
"PUB00054600": {
"PMID": 10786837,
"ISBN": null,
"volume": "101",
"issue": "2",
"year": 2000,
"title": "A kaiC-interacting sensory histidine kinase, SasA, necessary to sustain robust circadian oscillation in cyanobacteria.",
"URL": null,
"raw_pages": "223-33",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Iwasaki H",
"Williams SB",
"Kitayama Y",
"Ishiura M",
"Golden SS",
"Kondo T."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0092-8674(00)80832-6"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 364,
"pathways": 0,
"proteins": 364,
"proteomes": 222,
"sets": 0,
"structural_models": {
"alphafold": 280,
"bfvd": 0
},
"structures": 0,
"taxa": 785
},
"entry_annotations": {},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "2.7.13.3",
"url": "https://enzyme.expasy.org/EC/2.7.13.3"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
