General Handler

HTTP 200 OK
Allow: GET, HEAD
Cached: true
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Server-Timing: 
Vary: Accept

{
    "metadata": {
        "accession": "IPR022765",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF01930": "Domain of unknown function DUF83"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR022765",
            "name": "Dna2/Cas4, domain of unknown function DUF83",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Dna2/Cas4, domain of unknown function DUF83",
            "short": "Dna2/Cas4_DUF83"
        },
        "description": [
            {
                "text": "<p>This entry represents an uncharacterised domain found in several proteins, including DNA replication helicase Dna2, clustered regularly interspaced short palindromic repeats (CRISPR)-associated exonuclease Cas4 and putative RecB family exonuclease proteins.</p>\r\n\r\n<p>Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities. Cas4 has been shown to be a 5' to 3' single stranded DNA exonuclease in Sulfolobus solfataricus [[cite:PUB00063905]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00063905": {
                "PMID": 23056615,
                "ISBN": null,
                "volume": "7",
                "issue": "10",
                "year": 2012,
                "title": "The CRISPR associated protein Cas4 Is a 5' to 3' DNA exonuclease with an iron-sulfur cluster.",
                "URL": null,
                "raw_pages": "e47232",
                "medline_journal": "PLoS One",
                "ISO_journal": "PLoS ONE",
                "authors": [
                    "Zhang J",
                    "Kasciukovic T",
                    "White MF."
                ],
                "DOI_URL": "http://dx.doi.org/10.1371/journal.pone.0047232"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR011604",
                "name": "PD-(D/E)XK endonuclease-like domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 56,
            "interactions": 0,
            "matches": 6626,
            "pathways": 0,
            "proteins": 6606,
            "proteomes": 3858,
            "sets": 0,
            "structural_models": {
                "alphafold": 4851,
                "bfvd": 3
            },
            "structures": 10,
            "taxa": 9390
        },
        "entry_annotations": {
            "alignment:seed": 34,
            "alignment:full": 2988
        },
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "3.1.12.1",
                        "url": "https://enzyme.expasy.org/EC/3.1.12.1"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}