HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "IPR022645",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"prints": {
"PR01755": "SECFTRNLCASE"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR022813",
"name": "Protein-export membrane protein SecD/SecF, archaeal and bacterial",
"type": "Family",
"children": [
{
"accession": "IPR022645",
"name": "Protein-export membrane protein SecD/SecF, bacterial",
"type": "Family",
"children": [
{
"accession": "IPR005665",
"name": "Protein-export membrane protein SecF, bacterial",
"type": "Family",
"children": []
},
{
"accession": "IPR005791",
"name": "Protein translocase subunit SecD",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR024912",
"name": "Protein translocase subunit SecD, archaeal",
"type": "Family",
"children": []
},
{
"accession": "IPR024921",
"name": "Protein-export membrane protein SecF",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "Protein-export membrane protein SecD/SecF, bacterial",
"short": "SecD/SecF_bac"
},
"description": [
{
"text": "<p>Secretion across the inner membrane in some Gram-negative bacteria occurs via the preprotein translocase pathway. Proteins are produced in the cytoplasm as precursors, and require a chaperone subunit to direct them to the translocase component [[cite:PUB00007064]]. From there, the mature proteins are either targeted to the outer membrane, or remain as periplasmic proteins. The translocase protein subunits are encoded on the bacterial chromosome.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This entry represents bacterial SecD and SecF protein export membrane proteins. It is found in association with [pfam:PF07549] SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC [[cite:PUB00008120]]. SecD and SecF are required to maintain a proton motive force [[cite:PUB00020319]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00008120": {
"PMID": 9694879,
"ISBN": null,
"volume": "273",
"issue": "33",
"year": 1998,
"title": "SecDF of Bacillus subtilis, a molecular Siamese twin required for the efficient secretion of proteins.",
"URL": null,
"raw_pages": "21217-24",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Bolhuis A",
"Broekhuizen CP",
"Sorokin A",
"van Roosmalen ML",
"Venema G",
"Bron S",
"Quax WJ",
"van Dijl JM."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.273.33.21217"
},
"PUB00007065": {
"PMID": 11336818,
"ISBN": null,
"volume": "9",
"issue": "5",
"year": 2001,
"title": "SecB, a molecular chaperone with two faces.",
"URL": null,
"raw_pages": "193-6",
"medline_journal": "Trends Microbiol",
"ISO_journal": "Trends Microbiol.",
"authors": [
"Driessen AJ."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0966-842X(01)01980-1"
},
"PUB00007064": {
"PMID": 2202721,
"ISBN": null,
"volume": "22",
"issue": "3",
"year": 1990,
"title": "The sec and prl genes of Escherichia coli.",
"URL": null,
"raw_pages": "291-310",
"medline_journal": "J Bioenerg Biomembr",
"ISO_journal": "J. Bioenerg. Biomembr.",
"authors": [
"Bieker KL",
"Phillips GJ",
"Silhavy TJ."
],
"DOI_URL": "http://dx.doi.org/10.1007/BF00763169"
},
"PUB00007066": {
"PMID": 10418149,
"ISBN": null,
"volume": "176",
"issue": "1",
"year": 1999,
"title": "Effects of pre-protein overexpression on SecB synthesis in Escherichia coli.",
"URL": null,
"raw_pages": "219-27",
"medline_journal": "FEMS Microbiol Lett",
"ISO_journal": "FEMS Microbiol. Lett.",
"authors": [
"Muller JP."
],
"DOI_URL": null
},
"PUB00007187": {
"PMID": 12167867,
"ISBN": null,
"volume": "418",
"issue": "6898",
"year": 2002,
"title": "Three-dimensional structure of the bacterial protein-translocation complex SecYEG.",
"URL": null,
"raw_pages": "662-5",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Breyton C",
"Haase W",
"Rapoport TA",
"Kuhlbrandt W",
"Collinson I."
],
"DOI_URL": "http://dx.doi.org/10.1038/nature00827"
},
"PUB00020319": {
"PMID": 8112309,
"ISBN": null,
"volume": "13",
"issue": "4",
"year": 1994,
"title": "SecD and SecF are required for the proton electrochemical gradient stimulation of preprotein translocation.",
"URL": null,
"raw_pages": "954-63",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Arkowitz RA",
"Wickner W."
],
"DOI_URL": "http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=8112309"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 97028,
"pathways": 1,
"proteins": 25950,
"proteomes": 15820,
"sets": 0,
"structural_models": {
"alphafold": 19716,
"bfvd": 0
},
"structures": 6,
"taxa": 26727
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
