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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR021950",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0003712",
"name": "transcription coregulator activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0000124",
"name": "SAGA complex",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"panther": {
"PTHR13526": "TRANSCRIPTION FACTOR SPT20 HOMOLOG"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR021950",
"name": "Transcription factor Spt20",
"type": "Family",
"children": []
},
"name": {
"name": "Transcription factor Spt20",
"short": "Spt20"
},
"description": [
{
"text": "<p>This entry represents the Spt20 transcription factors in eukaryote organisms. The Spt20 protein is a subunit of the SAGA (Spt-Ada-Gcn5-acetyltransferase) complex, a large multiprotein complex involved in transcriptional regulation. In yeast, Spt20 plays a crucial role in maintaining the structural integrity of the SAGA complex, as no intact SAGA complex could be purified in Spt20 deletion strains. It is involved in chromatin organisation, histone acetylation, and IRE1-mediated unfolded protein response [[cite:PUB00101215]]. The human homologue of Spt20 (hSPT20) has been identified as a bona fide subunit of the human SAGA complex and is required for its integrity [[cite:PUB00101216]]. Functionally, Spt20 has been shown to participate in the regulation of specific genes. In yeast, it is required for the transcriptional elongation of PDR5 and the activation of seripauperin genes upon hypoxic stress exposure [[cite:PUB00101215]]. In human cells, hSPT20 and other hSAGA subunits are specifically recruited to genes induced by endoplasmic reticulum (ER) stress [[cite:PUB00101216], [cite:PUB00101214]].</p>",
"llm": false,
"checked": false,
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}
],
"wikipedia": null,
"literature": {
"PUB00101216": {
"PMID": 19114550,
"ISBN": null,
"volume": "29",
"issue": "6",
"year": 2009,
"title": "The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.",
"URL": null,
"raw_pages": "1649-60",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol Cell Biol",
"authors": [
"Nagy Z",
"Riss A",
"Romier C",
"le Guezennec X",
"Dongre AR",
"Orpinell M",
"Han J",
"Stunnenberg H",
"Tora L."
],
"DOI_URL": null
},
"PUB00101215": {
"PMID": 31969703,
"ISBN": null,
"volume": "577",
"issue": "7792",
"year": 2020,
"title": "Structure of the transcription coactivator SAGA.",
"URL": null,
"raw_pages": "717-720",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Wang H",
"Dienemann C",
"Stutzer A",
"Urlaub H",
"Cheung ACM",
"Cramer P."
],
"DOI_URL": null
},
"PUB00101214": {
"PMID": 31969704,
"ISBN": null,
"volume": "577",
"issue": "7792",
"year": 2020,
"title": "Structure of SAGA and mechanism of TBP deposition on gene promoters.",
"URL": null,
"raw_pages": "711-716",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Papai G",
"Frechard A",
"Kolesnikova O",
"Crucifix C",
"Schultz P",
"Ben-Shem A."
],
"DOI_URL": null
},
"PUB00095265": {
"PMID": 19056896,
"ISBN": null,
"volume": "22",
"issue": "22",
"year": 2008,
"title": "The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.",
"URL": null,
"raw_pages": "3184-95",
"medline_journal": "Genes Dev",
"ISO_journal": "Genes Dev.",
"authors": [
"Helmlinger D",
"Marguerat S",
"Villen J",
"Gygi SP",
"Bahler J",
"Winston F."
],
"DOI_URL": null
},
"PUB00062949": {
"PMID": 10026213,
"ISBN": null,
"volume": "274",
"issue": "9",
"year": 1999,
"title": "Expanded lysine acetylation specificity of Gcn5 in native complexes.",
"URL": null,
"raw_pages": "5895-900",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Grant PA",
"Eberharter A",
"John S",
"Cook RG",
"Turner BM",
"Workman JL."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.274.9.5895"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 5474,
"pathways": 1,
"proteins": 5474,
"proteomes": 2315,
"sets": 0,
"structural_models": {
"alphafold": 4116,
"bfvd": 0
},
"structures": 8,
"taxa": 6862
},
"entry_annotations": {},
"cross_references": {
"gp": {
"displayName": "Genome Properties",
"description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
"rank": 45,
"accessions": [
{
"accession": "GenProp2053",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp2053"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
