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{
    "metadata": {
        "accession": "IPR021625",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF11566": "PI31 proteasome regulator N-terminal"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR021625",
            "name": "PI31 proteasome regulator, N-terminal",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "PI31 proteasome regulator, N-terminal",
            "short": "PI31_Prot_N"
        },
        "description": [
            {
                "text": "<p>PI31 is a regulatory subunit of the immunoproteasome which is an inhibitor of the 20S proteasome in vitro. PI31 is also an Fbxo7.Skp1 binding partner. Fbxo7 is an F-box protein, which are the substrate-recognition components of the Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligases. The interaction between PI31 and Fbxo7.Skp1 occurs via the β sheets of a N-terminal domain present in both proteins and known as FP(Fbxo7/PI31) domain. The structure of PI31 FP domain contains a novel α/β-fold and two intermolecular contact surfaces [[cite:PUB00049891]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            },
            {
                "text": "<p>This entry represents the N-terminal domain of the PI31 proteasome regulator.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00049891": {
                "PMID": 18495667,
                "ISBN": null,
                "volume": "283",
                "issue": "32",
                "year": 2008,
                "title": "Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor.",
                "URL": null,
                "raw_pages": "22325-35",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Kirk R",
                    "Laman H",
                    "Knowles PP",
                    "Murray-Rust J",
                    "Lomonosov M",
                    "Meziane el K",
                    "McDonald NQ."
                ],
                "DOI_URL": "http://dx.doi.org/10.1074/jbc.M709900200"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 46,
            "interactions": 0,
            "matches": 5285,
            "pathways": 7,
            "proteins": 5270,
            "proteomes": 2761,
            "sets": 0,
            "structural_models": {
                "alphafold": 4772,
                "bfvd": 0
            },
            "structures": 5,
            "taxa": 7985
        },
        "entry_annotations": {
            "alignment:seed": 94,
            "alignment:full": 3561
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "4ouh",
            "name": "Crystal structure of the FP domain of Human PI31 Proteasome Inhibitor"
        }
    }
}