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{
    "metadata": {
        "accession": "IPR021591",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF11503": "YNR034W-A-like"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR021591",
            "name": "YNR034W-A/EGO2",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "YNR034W-A/EGO2",
            "short": "YNR034W-A/EGO2"
        },
        "description": [
            {
                "text": "<p>This family of proteins is predominantly found in Saccharomycetales, including YNR034W-A (also known as EGO4) and YCR075W-A (EGO2) from Saccharomyces cerevisiae. EGO2 is a component of the yeast EGO complex (EGOC), which is responsible for the amino acid-dependent activation of the target of rapamycin complex 1 (TORC1), a central controller of cell growth, metabolism, proliferation, and differentiation in response to environmental cues. EGO2 adopts a Roadblock domain fold that consists of a central core β-sheet of five anti-parallel β-strands flanked by a long α-helix on the bottom side. EGO4 shows a similar αββαββ configuration. It interacts with the GTPase Gtr2, but its specific function remains unknown [[cite:PUB00100979], [cite:PUB00100978]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00100979": {
                "PMID": 26206314,
                "ISBN": null,
                "volume": "25",
                "issue": "9",
                "year": 2015,
                "title": "Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling.",
                "URL": null,
                "raw_pages": "1043-59",
                "medline_journal": "Cell Res",
                "ISO_journal": "Cell Res",
                "authors": [
                    "Powis K",
                    "Zhang T",
                    "Panchaud N",
                    "Wang R",
                    "De Virgilio C",
                    "Ding J."
                ],
                "DOI_URL": null
            },
            "PUB00100978": {
                "PMID": 31579828,
                "ISBN": null,
                "volume": "5",
                "issue": "9",
                "year": 2019,
                "title": "Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases.",
                "URL": null,
                "raw_pages": "eaax8164",
                "medline_journal": "Sci Adv",
                "ISO_journal": "Sci Adv",
                "authors": [
                    "Zhang T",
                    "Peli-Gulli MP",
                    "Zhang Z",
                    "Tang X",
                    "Ye J",
                    "De Virgilio C",
                    "Ding J."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR035098",
                "name": "YNR034W-A/EGO2 superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 1,
            "interactions": 0,
            "matches": 86,
            "pathways": 0,
            "proteins": 86,
            "proteomes": 48,
            "sets": 0,
            "structural_models": {
                "alphafold": 79,
                "bfvd": 0
            },
            "structures": 5,
            "taxa": 116
        },
        "entry_annotations": {
            "alignment:seed": 13,
            "alignment:full": 36
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}