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{
    "metadata": {
        "accession": "IPR021043",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF12196": "FHA Ki67 binding domain of hNIFK"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR021043",
            "name": "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding",
            "short": "NIFK_FHA_Ki67-binding"
        },
        "description": [
            {
                "text": "<p>This entry represents eukaryotic proteins that contain a domain of approximately 40 amino acids in length. These proteins are found in association with [pfam:PF00076]. There are two conserved sequence motifs: TPVCTP and LERRKS. This domain is found on the human nucleolar protein hNIFK. It binds to the fork-head-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation [[cite:PUB00039266]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00039266": {
                "PMID": 16244663,
                "ISBN": null,
                "volume": "12",
                "issue": "11",
                "year": 2005,
                "title": "Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67.",
                "URL": null,
                "raw_pages": "987-93",
                "medline_journal": "Nat Struct Mol Biol",
                "ISO_journal": "Nat. Struct. Mol. Biol.",
                "authors": [
                    "Byeon IJ",
                    "Li H",
                    "Song H",
                    "Gronenborn AM",
                    "Tsai MD."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/nsmb1008"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 4,
            "interactions": 0,
            "matches": 893,
            "pathways": 0,
            "proteins": 893,
            "proteomes": 686,
            "sets": 0,
            "structural_models": {
                "alphafold": 824,
                "bfvd": 0
            },
            "structures": 25,
            "taxa": 2134
        },
        "entry_annotations": {
            "alignment:seed": 18,
            "alignment:full": 713
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}