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{
"metadata": {
"accession": "IPR020427",
"entry_id": null,
"type": "family",
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"prints": {
"PR01945": "Interleukin-11A"
}
},
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"hierarchy": {
"accession": "IPR020438",
"name": "Interleukin-11",
"type": "Family",
"children": [
{
"accession": "IPR020412",
"name": "Interleukin-11, mammalian",
"type": "Family",
"children": []
},
{
"accession": "IPR022356",
"name": "Interleukin-11, fish",
"type": "Family",
"children": [
{
"accession": "IPR020427",
"name": "Interleukin-11A, fish",
"type": "Family",
"children": []
},
{
"accession": "IPR020462",
"name": "Interleukin-11B, fish",
"type": "Family",
"children": []
}
]
}
]
},
"name": {
"name": "Interleukin-11A, fish",
"short": "IL-11A_fish"
},
"description": [
{
"text": "<p>Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.</p>\n\n<p>Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of IL-11 [[cite:PUB00013131]]. The cytokine also possesses anti-inflammatory activity, and has been proposed as a therapeutic agent in the treatment of chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis [[cite:PUB00046036]].</p>\n\n<p>Although IL-11 was initially believed to be restricted to mammals, subsequent studies demonstrated it to be expressed in ray-finned fish [[cite:PUB00046037], [cite:PUB00046038]]. Two fish paralogues have now been identified, designated IL-11A and IL-11B [[cite:PUB00046038]].</p>",
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"literature": {
"PUB00013131": {
"PMID": 9416001,
"ISBN": null,
"volume": "29",
"issue": "8-9",
"year": 1997,
"title": "Interleukin-11.",
"URL": null,
"raw_pages": "1059-62",
"medline_journal": "Int J Biochem Cell Biol",
"ISO_journal": "Int. J. Biochem. Cell Biol.",
"authors": [
"Leng SX",
"Elias JA."
],
"DOI_URL": "http://dx.doi.org/10.1016/S1357-2725(97)00017-4"
},
"PUB00046036": {
"PMID": 15992047,
"ISBN": null,
"volume": "7",
"issue": "9",
"year": 1998,
"title": "The therapeutic utility of Interleukin-11 in the treatment of inflammatory disease.",
"URL": null,
"raw_pages": "1501-4",
"medline_journal": "Expert Opin Investig Drugs",
"ISO_journal": null,
"authors": [
"Trepicchio WL",
"Dorner AJ."
],
"DOI_URL": "http://dx.doi.org/10.1517/13543784.7.9.1501"
},
"PUB00046037": {
"PMID": 15720388,
"ISBN": null,
"volume": "272",
"issue": "5",
"year": 2005,
"title": "Cloning and expression of the first nonmammalian interleukin-11 gene in rainbow trout Oncorhynchus mykiss.",
"URL": null,
"raw_pages": "1136-47",
"medline_journal": "FEBS J",
"ISO_journal": "FEBS J.",
"authors": [
"Wang T",
"Holland JW",
"Bols N",
"Secombes CJ."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1742-4658.2005.04544.x"
},
"PUB00046038": {
"PMID": 16003467,
"ISBN": null,
"volume": "57",
"issue": "6",
"year": 2005,
"title": "Multiple and highly divergent IL-11 genes in teleost fish.",
"URL": null,
"raw_pages": "432-43",
"medline_journal": "Immunogenetics",
"ISO_journal": "Immunogenetics",
"authors": [
"Huising MO",
"Kruiswijk CP",
"van Schijndel JE",
"Savelkoul HF",
"Flik G",
"Verburg-van Kemenade BM."
],
"DOI_URL": "http://dx.doi.org/10.1007/s00251-005-0012-2"
},
"PUB00046050": {
"PMID": 18538848,
"ISBN": null,
"volume": "45",
"issue": "12",
"year": 2008,
"title": "Teleostean IL11b exhibits complementing function to IL11a and expansive involvement in antibacterial and antiviral responses.",
"URL": null,
"raw_pages": "3494-501",
"medline_journal": "Mol Immunol",
"ISO_journal": "Mol. Immunol.",
"authors": [
"Santos MD",
"Yasuike M",
"Kondo H",
"Hirono I",
"Aoki T."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.molimm.2008.02.004"
}
},
"set_info": null,
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{
"accession": "IPR009079",
"name": "Four-helical cytokine-like, core",
"type": "homologous_superfamily"
}
],
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},
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"taxa": 471
},
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}
