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{
"metadata": {
"accession": "IPR020162",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0021549",
"name": "cerebellum development",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0030182",
"name": "neuron differentiation",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
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"pfam": {
"PF15677": "Cell cycle exit and neuronal differentiation protein 1"
},
"panther": {
"PTHR36683": "CELL CYCLE EXIT AND NEURONAL DIFFERENTIATION PROTEIN 1"
}
},
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"hierarchy": {
"accession": "IPR020162",
"name": "Cell cycle exit/neuronal differentiation protein 1",
"type": "Family",
"children": []
},
"name": {
"name": "Cell cycle exit/neuronal differentiation protein 1",
"short": "Cend1"
},
"description": [
{
"text": "<p>Cell cycle exit and neuronal differentiation protein 1 (Cend1 or BM88) is a homodimer of 140 amino acids. It has a putative transmembrane domain at the C terminus. The mRNA of this protein is expressed only in neural tissues, where it is restricted to neurons. It is involved in neuroblastoma cell differentiation [[cite:PUB00045934], [cite:PUB00075749]], neuronal differentiation [[cite:PUB00075748]], and development of the cerebellum [[cite:PUB00075747]].</p>",
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"PUB00045934": {
"PMID": 7775480,
"ISBN": null,
"volume": "270",
"issue": "23",
"year": 1995,
"title": "The BM88 antigen, a novel neuron-specific molecule, enhances the differentiation of mouse neuroblastoma cells.",
"URL": null,
"raw_pages": "14201-8",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Mamalaki A",
"Boutou E",
"Hurel C",
"Patsavoudi E",
"Tzartos S",
"Matsas R."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.270.23.14201"
},
"PUB00075747": {
"PMID": 20153830,
"ISBN": null,
"volume": "44",
"issue": "1",
"year": 2010,
"title": "Impaired cerebellar development and deficits in motor coordination in mice lacking the neuronal protein BM88/Cend1.",
"URL": null,
"raw_pages": "15-29",
"medline_journal": "Mol Cell Neurosci",
"ISO_journal": "Mol. Cell. Neurosci.",
"authors": [
"Sergaki MC",
"Guillemot F",
"Matsas R."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.mcn.2010.01.011"
},
"PUB00075748": {
"PMID": 23658157,
"ISBN": null,
"volume": "33",
"issue": "19",
"year": 2013,
"title": "Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.",
"URL": null,
"raw_pages": "8172-84",
"medline_journal": "J Neurosci",
"ISO_journal": "J. Neurosci.",
"authors": [
"Weng L",
"Lin YF",
"Li AL",
"Wang CE",
"Yan S",
"Sun M",
"Gaertig MA",
"Mitha N",
"Kosaka J",
"Wakabayashi T",
"Xu X",
"Tang B",
"Li S",
"Li XJ."
],
"DOI_URL": "http://dx.doi.org/10.1523/JNEUROSCI.0119-13.2013"
},
"PUB00075749": {
"PMID": 24312406,
"ISBN": null,
"volume": "8",
"issue": "11",
"year": 2013,
"title": "Functional Interactions between BM88/Cend1, Ran-binding protein M and Dyrk1B kinase affect cyclin D1 levels and cell cycle progression/exit in mouse neuroblastoma cells.",
"URL": null,
"raw_pages": "e82172",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS ONE",
"authors": [
"Tsioras K",
"Papastefanaki F",
"Politis PK",
"Matsas R",
"Gaitanou M."
],
"DOI_URL": "http://dx.doi.org/10.1371/journal.pone.0082172"
}
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},
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"taxa": 1802
},
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},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
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"representative_structure": null
}
}
